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. 2018 Jun;110(6):534-541.
doi: 10.5935/abc.20180079.

Is There any Relationship Between Myocardial Repolarization Parameters and the Frequency of Ventricular Premature Contractions?

[Article in English, Portuguese]
Kayihan Karaman  1 , Metin Karayakali  1 , Arif Arisoy  1 , Ilker Akar  2 , Mustafa Ozturk  3 , Ahmet Yanik  4 , Samet Yilmaz  1 , Atac Celik  1
Affiliations

Is There any Relationship Between Myocardial Repolarization Parameters and the Frequency of Ventricular Premature Contractions?

[Article in English, Portuguese]
Kayihan Karaman et al. Arq Bras Cardiol. 2018 Jun.

Abstract

Background: Ventricular premature contractions (VPCs) may trigger lethal ventricular arrhythmias in patients with structural heart disease. However, this role of VPCs in healthy people remains controversial once that not enough clinical trials are available. Recently, some myocardial repolarization markers, such as Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios, have been reported to be useful for predicting lethal ventricular arrhythmias in various clinical disorders without structural heart disease.

Objective: In this study, we aimed to investigate the relation between VPC frequent and myocardial repolarization markers in individuals without structural heart disease.

Methods: This study included 100 patients who had complaints of dizziness and palpitations. Twelve-lead electrocardiography and 24-hour ambulatory Holter recordings were obtained from all patients. VPC burden was calculated as the total number of VPCs divided by the number of all QRS complexes in the total recording time. P-values < 0.05 were considered significant.

Results: Tp-e interval and Tp-e/QTc ratio were significantly higher in patients with higher VPC burden than in patients with lower VPC burden, and a positive correlation was found between these markers and VPC burden. Tp-e (β = 1.318, p = 0.043) and Tp-e/QTc (β = -405.136, p = 0.024) in the lead V5 were identified as independent predictors of increased VPC burden.

Conclusions: Tp-e interval and Tp-e/QTc ratio increased in patients with high VPC number. Our study showed that VPCs may have a negative effect on myocardial repolarization. This interaction may lead to an increased risk of malignant arrhythmias.

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Conflict of interest statement

Potential Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Scatter analysis of the correlation between the Tp-e interval and Tp-e/QTc ratio (in the leads V2 and V5) and the VPC burden. ms: millisecond; QTc: corrected QT; Tp-e: T wave peak-to-end interval; VPC: ventricular premature contraction.
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