Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jan:138:26-32.
doi: 10.1016/j.neures.2018.09.012. Epub 2018 Sep 15.

Elucidating the developmental trajectories of GABAergic cortical interneuron subtypes

Affiliations
Review

Elucidating the developmental trajectories of GABAergic cortical interneuron subtypes

Goichi Miyoshi. Neurosci Res. 2019 Jan.

Abstract

GABAergic interneurons in the neocortex play pivotal roles in the feedforward and feedback inhibition that control higher order information processing and thus, malfunction in the inhibitory circuits often leads to neurodevelopmental disorders. Very interestingly, a large diversity of morphology, synaptic targeting specificity, electrophysiological properties and molecular expression profiles are found in cortical interneurons, which originate within the distantly located embryonic ganglionic eminences. Here, I will review the still ongoing effort to understand the developmental trajectories of GABAergic cortical interneuron subtypes.

Keywords: Clonal analysis; Fate mapping; Ganglionic eminence; MGE and CGE; Migration; Single cell RNA sequencing; Transcription factor.

PubMed Disclaimer

Similar articles

Cited by

MeSH terms

LinkOut - more resources