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Review
. 2018 Sep 17;16(9):339.
doi: 10.3390/md16090339.

Natural Product Chemistry of Gorgonian Corals of Genus Junceella⁻Part III

Hsu-Ming Chung  1 , Yi-Chen Wang  2 , Chung-Chih Tseng  3   4 , Nan-Fu Chen  5   6 , Zhi-Hong Wen  7 , Lee-Shing Fang  8   9 , Tsong-Long Hwang  10   11   12   13 , Yang-Chang Wu  14   15   16   17 , Ping-Jyun Sung  18   19   20   21   22
Affiliations
Review

Natural Product Chemistry of Gorgonian Corals of Genus Junceella⁻Part III

Hsu-Ming Chung et al. Mar Drugs. .

Abstract

The structures, names, bioactivities, and references of 82 natural products, including 48 new metabolites, purified from the gorgonian corals belonging to the genus Junceella are described in this review. All compounds mentioned in this review were obtained from Junceella fragilis, Junceella gemmacea, Junceella juncea, and Junceella sp., collected from tropical Indo-Pacific Ocean. Some of these compounds exhibited potential biomedical activities.

Keywords: Junceella; biomedical activity; briarane; gorgonian.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Structures of frajunolides P–S (1–4), umbraculolide A (5), juncenolide C (6), junceellonoid A (7), and juncin R (8).
Figure 2
Figure 2
Structures of fragilisinins A–L (9–20), junceellolides A (21) and B (22), junceol A (23), junceellonoid D (24), fragilide C (25), and frajunolides A (26) and E (27).
Figure 3
Figure 3
Structures of fragilolides A–Q (28–44), frajunolides H (45) and N (46), scabrolide D (47), sinuleptolide (48), and 5-epi-sinuleptolide (49).
Figure 3
Figure 3
Structures of fragilolides A–Q (28–44), frajunolides H (45) and N (46), scabrolide D (47), sinuleptolide (48), and 5-epi-sinuleptolide (49).
Figure 4
Figure 4
Structures of 3-deacetylpraelolide (50), 13-α-acetoxy-3-deacetylpraelolide (51), 13-α- acetoxy-2-deacetylpraelolide (52), 13-α-acetoxy-3-deacetyljunceellin (53), 13-α-acetoxy-2-deacetyl- junceellin (54), fragilide J (55), 3-deacetyljunceellin (56), and 2-deacetyljunceellin (57).
Figure 5
Figure 5
Structures of fragilides K (58) and L (59), gemmacolides V (60) and X (61), praelolide (62), juncins P (63) and ZI (64).
Figure 6
Figure 6
Structures of junceellolides M–P (65–68), junceellolides C (69) and D (70), and junceellin A (71).
Figure 7
Figure 7
Structures of (1S*,2S*,8S*,9S*,10S*,11R*,12R*,14S*,17R*)-11,20-epoxy-14-(3-methyl- butanoyl)-2,9,12-triacetoxy-8-hydroxybriar-5(16)-en-18,7-olide (72), gemmacolides A (73) and B (74), and juncins H (75) and K (76).
Figure 8
Figure 8
Structures of juncenolides M–O (77–79).
Figure 9
Figure 9
Structures of 5α,8α-epidioxy-24(ξ)-methylcholesta-6,22-dien-3β-ol (80), deoxyadenosine (81), and deoxythymidine (82).
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References

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