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. 2018 Dec:206:127-130.
doi: 10.1016/j.ahj.2018.08.007. Epub 2018 Aug 24.

Randomized trial of rivaroxaban versus warfarin in the evaluation of progression of coronary atherosclerosis

Juhwan Lee  1 , Rine Nakanishi  1 , Dong Li  1 , Kashif Shaikh  1 , Chandana Shekar  1 , Kazuhiro Osawa  1 , Negin Nezarat  1 , Eranthi Jayawardena  1 , Maja Blanco  1 , Matthew Chen  1 , Matthew Sieckert  1 , Eric Nelson  1 , Darius Billingsley  1 , Sajad Hamal  1 , Matthew J Budoff  2
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Randomized trial of rivaroxaban versus warfarin in the evaluation of progression of coronary atherosclerosis

Juhwan Lee et al. Am Heart J. 2018 Dec.

Abstract

Warfarin, a vitamin K antagonist, is associated with systemic vascular calcification. We evaluated whether rivaroxaban (a direct oral factor Xa inhibitor with no interaction with vitamin K) will slow the progression in coronary plaque volumes compared with warfarin in patients with nonvalvular atrial fibrillation using coronary computed tomography angiography.

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