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Review
. 2018 Mar-Apr;115(2):151-155.

Prostate Cancer Pathology: Recent Updates and Controversies

Affiliations
Review

Prostate Cancer Pathology: Recent Updates and Controversies

Jennifer K Sehn. Mo Med. 2018 Mar-Apr.

Abstract

Prostate cancer is common, and recent efforts in clinical management have focused on identifying patients who could be candidates from less aggressive management or who could benefit from more aggressive therapy. As prostate cancer histology, especially Gleason score, plays a critical role in predicting patient outcomes, attempts have been made to refine histologic classification and reporting in prostate cancer to facilitate patient risk stratification. This review discusses recent updates in prostate cancer grading and reporting.

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Figures

Figure 1
Figure 1
Illustrates the current state of Gleason grading in comparison with the original system proposed by Gleason himself.
None

References

    1. Epstein JI, Egvad L, Amin MB, Delahunt B, et al. The 2014 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma: definition of grading patterns and proposal for a new grading system. Am J Surg Pathol. 2016;40:244–252. - PubMed
    1. Moch H, Humphrey PA, Ulbright TM, Reuter VE, editors. WHO classification of tumors of the urinary system and male genital organs. 4th ed. IARC; Lyon, France: 2016. - PubMed
    1. Srigley JR, Delahunt B, Evans AJ. Therapy-associated effects in the prostate gland. Histopathology. 2012;60:153–165. - PubMed
    1. Epstein JI, Zelefsky MJ, Sjoberg DD, et al. A contemporary prostate cancer grading system: a validated alternative to the Gleason score. Eur Urol. 2016;69:428–435. - PMC - PubMed
    1. Srigley JR, Zhou M, Amin MB, et al. College of American Pathologists protocol for the examination of specimens from patients with carcinoma of the prostate gland. [Accessed: 6/14/2017]. Version: Prostate 3.3.0.0, revised February 28, 2017 www.cap.org/cancerprotocols.