Is APOE ε4 required for Alzheimer's disease to develop in TREM2 p.R47H variant carriers?
- PMID: 30229991
- PMCID: PMC6380937
- DOI: 10.1111/nan.12517
Is APOE ε4 required for Alzheimer's disease to develop in TREM2 p.R47H variant carriers?
Conflict of interest statement
Conflicts of interest
The authors have no conflicts of interest.
Comment on
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APOE ε4 is also required in TREM2 R47H variant carriers for Alzheimer's disease to develop.Neuropathol Appl Neurobiol. 2019 Feb;45(2):183-186. doi: 10.1111/nan.12474. Epub 2018 Mar 1. Neuropathol Appl Neurobiol. 2019. PMID: 29411406 No abstract available.
References
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- Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, et al. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 2016. October 5;92(1):252–64. - PubMed
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- Yeh FL, Wang Y, Tom I, Gonzalez LC, Sheng M. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. 2016. July 20;91(2):328–40. - PubMed
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