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. 2018 Dec;93(12):1439-1443.
doi: 10.1002/ajh.25289. Epub 2018 Oct 23.

The missing middle of sickle therapeutics: Multi-agent therapy, targeting risk, using biomarkers

Robert P Hebbel  1 , Jacques Elion  2 , Abdullah Kutlar  3
Affiliations

The missing middle of sickle therapeutics: Multi-agent therapy, targeting risk, using biomarkers

Robert P Hebbel et al. Am J Hematol. 2018 Dec.
No abstract available

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Figures

Figure 1
Figure 1
The vicious cycle of SCA, with ischemia/reperfusion pathophysiology as the driver of incessant, systemic inflammation
Figure 2
Figure 2
Taming the instability of “steady state.” (A) Instability of steady state is shown by biomarkers sampled longitudinally from three historically mild SCA subjects, without current symptoms, and no acute events >3 months before or after this study. Each symbol type indicates one of the subjects. For each biomarker, the shaded area indicates range for normal subjects. (B) Testing for efficacy while controlling for instability. Here, efficacy of oral sulfasalazine for downregulating endothelial adhesion molecule expression in one SCA subject was tested. Activation is expressed as % of circulating endothelial cells (CEC) positive for three adhesion molecules (open symbols) and tissue factor (closed symbol). Steady state baseline is established empirically by all values collected off‐drug (the box). Dark bars show days on‐drug; the indicated day numbers identify the start and stop dates for the mini‐trials. Figure reproduced with permission from Ref. 13
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