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. 1977 Oct 1;146(4):1138-42.
doi: 10.1084/jem.146.4.1138.

Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers

J J Mond, R Lieberman, J K Inman, D E Mosier, W E Paul

Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers

J J Mond et al. J Exp Med. .

Abstract

Mice with the CBA/N defect are unresponsive to the hapten phosphorylcholine (PC) even when presented on a variety of immunogenic carriers. Since these mice have the variable region gene for PC, their inability to respond may reflect deletion or suppression of the line of B lymphocytes which is responsible for the anti-PC response.

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