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Comment
. 2018 Sep 18;49(3):379-381.
doi: 10.1016/j.immuni.2018.08.026.

Ion Man: GSDMD Punches Pores to Knock Out cGAS

Rebecca Feltham  1 , James E Vince  2
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Ion Man: GSDMD Punches Pores to Knock Out cGAS

Rebecca Feltham et al. Immunity. .
Free article

Abstract

The pore-forming protein GSDMD promotes cytokine release and induces pyroptotic cell death. In this issue of Immunity, Banerjee et al. (2018) document how GSDMD triggers potassium efflux to inhibit cGAS-STING and prevent damaging interferon production after bacterial infection.

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