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Comment
. 2018 Sep 18;49(3):394-396.
doi: 10.1016/j.immuni.2018.09.001.

Tissue Crosstalk in T1D: Is Insulin Special?

Braxton L Jamison  1 , Kathryn Haskins  2
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Tissue Crosstalk in T1D: Is Insulin Special?

Braxton L Jamison et al. Immunity. .
Free article

Abstract

In a recent issue of Nature,Wan et al. (2018) show that glucose-stimulated β cells secrete insulin B chain peptides relevant to autoimmunity in type 1 diabetes. Peptides such as insulin B:12-20 are released into circulation, where they can be directly and broadly presented by antigen-presenting cells throughout the lymphatic system.

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