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Meta-Analysis
. 2018 Oct 17;38(5):BSR20180942.
doi: 10.1042/BSR20180942. Print 2018 Oct 31.

The potential role of MGMT rs12917 polymorphism in cancer risk: an updated pooling analysis with 21010 cases and 34018 controls

Zhiguo Sheng  1 , Meini Kang  2 , Hao Wang  3
Affiliations
Meta-Analysis

The potential role of MGMT rs12917 polymorphism in cancer risk: an updated pooling analysis with 21010 cases and 34018 controls

Zhiguo Sheng et al. Biosci Rep. .

Erratum in

Abstract

In the present study, we aimed at determining the potential role of rs12917 polymorphism of the O-6-methylguanine-DNA methyltransferase (MGMT) gene in the occurrence of cancer. Based on the available data from the online database, we performed an updated meta-analysis. We retrieved 537 articles from our database research and finally selected a total of 54 case-control studies (21010 cases and 34018 controls) for a series of pooling analyses. We observed an enhanced risk in cancer cases compared with controls, using the genetic models T/T compared with C/C (P-value of association test <0.001; odds ratio (OR) = 1.29) and T/T compared with C/C+C/T (P<0.001; OR = 1.32). We detected similar positive results in the subgroups 'Caucasian', and 'glioma' (all P<0.05; OR > 1). However, we detected negative results in our analyses of most of the other subgroups (P>0.05). Begg's and Egger's tests indicated that the results were free of potential publication bias, and sensitivity analysis suggested the stability of the pooling results. In summary, the T/T genotype of MGMT rs12917 is likely to be linked to an enhanced susceptibility to cancer overall, especially glioma, in the Caucasian population.

Keywords: Cancer; MGMT; meta-analysis; polymorphism.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. Flowchart for the identification of eligible case–control studies
Figure 2
Figure 2. Forest plot of meta-analysis (T/T compared with C/C model)
Figure 3
Figure 3. Forest plot of subgroup analysis by race (T/T compared with C/C model)
Figure 4
Figure 4. Begg’s funnel plot with pseudo-95% confidence limits (T/T compared with C/C model)
Figure 5
Figure 5. Sensitivity analysis result (T/T compared with C/C model)
See this image and copyright information in PMC

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