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. 2018 Oct 5;20(19):6302-6305.
doi: 10.1021/acs.orglett.8b02819. Epub 2018 Sep 20.

Palladium-Mediated Site-Selective C-H Radio-iodination

Emmanuelle Dubost  1 , Victor Babin  1 , Florian Benoist  1 , Alexandra Hébert  1 , Pierre Barbey  2 , Céline Chollet  3 , Jean-Philippe Bouillon  4 , Alain Manrique  5   6 , Grégory Pieters  3 , Frédéric Fabis  1 , Thomas Cailly  1   6
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Palladium-Mediated Site-Selective C-H Radio-iodination

Emmanuelle Dubost et al. Org Lett. .

Abstract

The palladium-mediated C-H radio-iodination of arenes using sodium iodide as the primary isotopic source is reported and performed without chemical know-how in 30 min and applied to the synthesis of complex radio-iodinated compounds of biological interest.

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