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Editorial
. 2018 Aug;10(8):4682-4685.
doi: 10.21037/jtd.2018.07.66.

Immunotherapy and molecular role of T-cell in PD-1 antibody treated resectable lung cancer patients

Samaresh Sau  1 , Arun K Iyer  1   2
Affiliations
Editorial

Immunotherapy and molecular role of T-cell in PD-1 antibody treated resectable lung cancer patients

Samaresh Sau et al. J Thorac Dis. 2018 Aug.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
(A) Innate immune resistance is driven by activation of PI3K/Akt kinase and IL-6/STAT3 oncogenic signaling that up-modulate PDL-1 protein expression in tumor cells, resulting PD-1/PD-L1 complexation; (B) the adaptive immune resistance of cancer cells is the outcome of INF-γ responded PD-L1 expression. MHC and TCR interaction helps T-cell activation. Figure and legend were adopted with permission from reference (1). PD-L1, program death ligand-1; PD-1, program death-1; MHC, major histocompatibility complex; TCR, T-cell receptor.
Figure 2
Figure 2
Ongoing international clinical trials including Chinese patients. (A) Between January 01, 2013, and April 06, 2017, there were 270 clinical trials of anti-PD-1/PD-L1 inhibitors for NSCLC that were registered on ClinicalTrials.gov. Among the 270 studies, 61 studies were performed in East Asia and 14 studies were performed in China (12 multinational trials and 2 trials that only evaluated Chinese patients); (B) the 14 clinical trials included six first-line studies, four second-line studies, two adjuvant therapy studies, and two phase I studies for only Chinese patients; (C) the classification of clinical trials in China according to the therapeutic agent, which includes nivolumab, pembrolizumab, atezolizumab, and durvalumab. The image and legend were adopted with permission from reference (8). PD-L1, program death ligand-1; PD-1, program death-1.
See this image and copyright information in PMC

Comment on

  • Neoadjuvant PD-1 Blockade in Resectable Lung Cancer.
    Forde PM, Chaft JE, Smith KN, Anagnostou V, Cottrell TR, Hellmann MD, Zahurak M, Yang SC, Jones DR, Broderick S, Battafarano RJ, Velez MJ, Rekhtman N, Olah Z, Naidoo J, Marrone KA, Verde F, Guo H, Zhang J, Caushi JX, Chan HY, Sidhom JW, Scharpf RB, White J, Gabrielson E, Wang H, Rosner GL, Rusch V, Wolchok JD, Merghoub T, Taube JM, Velculescu VE, Topalian SL, Brahmer JR, Pardoll DM. Forde PM, et al. N Engl J Med. 2018 May 24;378(21):1976-1986. doi: 10.1056/NEJMoa1716078. Epub 2018 Apr 16. N Engl J Med. 2018. PMID: 29658848 Free PMC article. Clinical Trial.

References

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