Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019;26(5):477-482.
doi: 10.5603/CJ.a2018.0108. Epub 2018 Sep 20.

The usefulness of selected biomarkers in aortic regurgitation

Piotr Duchnowski  1 , Tomasz Hryniewiecki  2 , Mariusz Kuśmierczyk  3 , Piotr Szymański  2
Affiliations

The usefulness of selected biomarkers in aortic regurgitation

Piotr Duchnowski et al. Cardiol J. 2019.

Abstract

Background: The aim of the study was to investigate the prognostic value of selected biomarkers in patients with aortic regurgitation undergoing valve surgery.

Methods: A prospective study was conducted on a group of consecutive patients with hemodynamically significant aortic regurgitation that underwent elective aortic valve surgery. The primary endpoint was 30-day mortality and any major adverse event within 30 days.

Results: The study group included 205 consecutive patients who underwent replacement or repair of the aortic valve. The primary endpoint occurred in 72 patients. At multivariate analysis red cell distribution width (RDW; p = 0.03) and high-sensitivity troponin T (hs-TnT; p = 0.02) remained independent predictors of the major complications including death.

Conclusions: Elevated preoperative RDW and hs-TnT were associated with a poorer outcome following aortic valve surgery.

Keywords: EuroSCORE II; aortic regurgitation; biomarkers; high-sensitivity troponin T; risk stratification.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None declared

Figures

Figure 1
Figure 1
Areas under receiver operator characteristic curves of EuroSCORE II (ESII) and combined model EuroSCORE II + high sensitivity troponin T (hs-TnT) + red cell distribution width (RDW) for 30-day major complications including death following aortic valve surgery; AUC — area under curve.
See this image and copyright information in PMC

References

    1. Grąbczewska Z, Dębski R, Góralczyk K, et al. Associations between selected angiographic parameters and the number of CD34+ cells and plasma levels of vascular endothelial growth factor and angiogenin in patients with ST-segment elevation myocardial infarction. Pol Arch Med Wewn. 2015;125(3):132–140. - PubMed
    1. Reichlin T, Schindler C, Drexler B, et al. One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. Arch Intern Med. 2012;172(16):1211–1218. doi: 10.1001/archinternmed.2012.3698. - DOI - PubMed
    1. Koide K, Yoshikawa T, Nagatomo Y, et al. Elevated troponin T on discharge predicts poor outcome of decompensated heart failure. Heart Vessels. 2010;25(3):217–222. doi: 10.1007/s00380-009-1194-6. - DOI - PubMed
    1. Gualandro DM, Puelacher C, Mueller C. High-sensitivity cardiac troponin in acute conditions. Curr Opin Crit Care. 2014;20(5):472–477. doi: 10.1097/MCC.0000000000000132. - DOI - PubMed
    1. Kawahara C, Tsutamoto T, Nishiyama K, et al. Prognostic role of high-sensitivity cardiac troponin T in patients with nonischemic dilated cardiomyopathy. Circ J. 2011;75(3):656–661. - PubMed

MeSH terms

LinkOut - more resources