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Case Reports
. 2018 Sep;97(38):e12000.
doi: 10.1097/MD.0000000000012000.

A CARE-compliant article: Extranasal glial heterotopia in a female infant: A case report

Weigang Gan  1 , Yu Xiang, Yiping Tang, Xinrong He, Juanjuan Hu, Fengjuan Yang, Shixi Liu, Junming Xian, Juan Meng
Affiliations
Case Reports

A CARE-compliant article: Extranasal glial heterotopia in a female infant: A case report

Weigang Gan et al. Medicine (Baltimore). 2018 Sep.

Abstract

Rationale: Nasal glial heterotopia is a rare type of neoplasm consisting of meningothelial and/or neuroglial elements.

Patient concerns: A 17-month-old female infant was evaluated for treatment for a congenital mass present since birth on the right side of the nasal dorsum.

Diagnoses: The patient was preoperatively diagnosed with a congenital extranasal neoplasm.

Interventions: Surgery was performed under general anesthesia, and the mass was completely resected. The tissue was sent for histological examination, and the diagnosis was of extranasal glial heterotopia.

Outcomes: The surgical outcome was good, and no surgical site infection was recorded. After 6 months of follow-up, the girl was asymptomatic with no recurrence.

Lessons: Surgical excision, a curative method used to address extranasal glial heterotopia, resulted in no recurrence during the clinical follow-up period. The potential for an intracranial connection must always be kept in mind when considering how to surgically treat a congenital midline mass to prevent the risk of cerebrospinal fluid leakage.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
A rubbery, movable, and well-demarcated nodule was observed on the right side of the nose.
Figure 2
Figure 2
Computed tomography scan showing a nasal mass (arrows) arising from subcutaneous tissue connected with the nasal bone. An magnetic resonance imaging of the nasal mass (arrows) with low T1 and T2 signals showing that the mass had no connection with the brain.
Figure 3
Figure 3
The nasal bone was exposed after lump resection, and its gross pathology showed a soft mass measuring 1.5 cm across the largest dimension.
Figure 4
Figure 4
Neuroglial heterotopia composed of glial cells and neuroglial fibers. Hematoxylin and eosin: (A) ×100, (B) ×400.
Figure 5
Figure 5
Immunohistochemistry: The neuroglial tissue was positively stained for glial fibrillary acidic protein. (C) ×100, (D) ×400.
See this image and copyright information in PMC

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References

    1. Rouev P, Dimov P, Shomov G. A case of nasal glioma in a new-born infant. Int J Pediatr Otorhinolaryngol 2001;58:91–4. - PubMed
    1. Hughes GB, Sharpino G, Hunt W, et al. Management of the congenital midline nasal mass: a review. Head Neck Surg 1980;2:222–33. - PubMed
    1. Bradley PJ, Singh SD. Congenital nasal masses: diagnosis and management. Clin Otolaryngol Allied Sci 1982;7:87–97. - PubMed
    1. Hedlund G. Congenital frontonasal masses: developmental anatomy, malformations, and MR imaging. Pediatr Radiol 2006;36:647–62. - PubMed
    1. Altissimi G, Ascani S, Falcetti S, et al. Central nervous system tissue heterotopia of the nose: case report and review of the literature. Acta Otorhinolaryngol Ital 2009;29:218–21. - PMC - PubMed

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