Exosomal miR-1246 in body fluids is a potential biomarker for gastrointestinal cancer
- PMID: 30235938
- DOI: 10.2217/bmm-2017-0440
Exosomal miR-1246 in body fluids is a potential biomarker for gastrointestinal cancer
Abstract
Aim: The aim was to systematically evaluate whether exosomal miRNAs could be regarded as potential minimally invasive biomarkers of diagnosis for gastrointestinal cancer.
Methods: A systematic review and meta analysis of exosomal miRNA expression in gastrointestinal cancer were performed.
Results: A total of 370 articles were retrieved from PubMed and EMBASE. The summary receiver operating characteristic curves of three miRNAs (miR-21, miR-1246 and miR-4644) were drawn, miR-21, miR-1246 and miR-4644 exhibited sensitivities of 0.66, 0.920 and 0.750, respectively; specificities were 0.87, 0.958 and 0.769, respectively; and areas under the curve for discriminating gastrointestinal cancer patients from control subjects were 0.876, 0.969 and 0.827, respectively.
Conclusion: Exosome miR-1246 had the highest level of diagnostic efficiency, which indicated that miR-1246 could be a biomarker.
Keywords: SROC; biomarkers; exosome; gastrointestinal cancer; miR-1246; microRNA.
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