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Comment
. 2018 Sep 19;99(6):1102-1104.
doi: 10.1016/j.neuron.2018.09.006.

Peripheral Kappa Opioid Receptor Signaling Takes on a Central Role

Paul V Naser  1 , Rohini Kuner  2
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Free article
Comment

Peripheral Kappa Opioid Receptor Signaling Takes on a Central Role

Paul V Naser et al. Neuron. .
Free article

Abstract

With the current unmet demand for effective analgesics and the opioid crisis, pain relief without major central adverse effects is highly appealing. In this issue of Neuron, Snyder et al. (2018) report on the localization, functions, and therapeutic potential of kappa opioid receptors in peripheral sensory neurons.

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Comment on

  • Kappa Opioid Receptor Distribution and Function in Primary Afferents.
    Snyder LM, Chiang MC, Loeza-Alcocer E, Omori Y, Hachisuka J, Sheahan TD, Gale JR, Adelman PC, Sypek EI, Fulton SA, Friedman RL, Wright MC, Duque MG, Lee YS, Hu Z, Huang H, Cai X, Meerschaert KA, Nagarajan V, Hirai T, Scherrer G, Kaplan DH, Porreca F, Davis BM, Gold MS, Koerber HR, Ross SE. Snyder LM, et al. Neuron. 2018 Sep 19;99(6):1274-1288.e6. doi: 10.1016/j.neuron.2018.08.044. Neuron. 2018. PMID: 30236284 Free PMC article.

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