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. 1987 Jan;61(1):134-42.
doi: 10.1128/JVI.61.1.134-142.1987.

Characterization of a transcriptional promoter of human papillomavirus 18 and modulation of its expression by simian virus 40 and adenovirus early antigens

F Thierry, J M Heard, K Dartmann, M Yaniv

Characterization of a transcriptional promoter of human papillomavirus 18 and modulation of its expression by simian virus 40 and adenovirus early antigens

F Thierry et al. J Virol. 1987 Jan.

Abstract

RNA present in cells derived from cervical carcinoma that contained human papillomavirus 18 genomes was initiated in the 1.053-kilobase BamHI fragment that covered the complete noncoding region of this virus. When cloned upstream of the chloramphenicol acetyltransferase gene, this viral fragment directed the expression of the bacterial enzyme only in the sense orientation. Initiation sites were mapped around the ATG of open reading frame E6. This promoter was active in some human and simian cell lines, and its expression was modulated positively by simian virus 40 large T antigen and negatively by adenovirus type 5 E1a antigen.

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References

    1. Cell. 1984 Dec;39(3 Pt 2):653-62 - PubMed
    1. Nature. 1984 Dec 13-19;312(5995):608-12 - PubMed
    1. J Virol. 1985 Mar;53(3):735-41 - PubMed
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    1. Proc Natl Acad Sci U S A. 1985 Feb;82(4):1030-4 - PubMed

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