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Comparative Study
. 1987 Jan;61(1):225-8.
doi: 10.1128/JVI.61.1.225-228.1987.

Varicella-zoster virus complements herpes simplex virus type 1 temperature-sensitive mutants

J M Felser, S E Straus, J M Ostrove
Comparative Study

Varicella-zoster virus complements herpes simplex virus type 1 temperature-sensitive mutants

J M Felser et al. J Virol. 1987 Jan.

Abstract

Varicella-zoster virus (VZV) can complement temperature-sensitive mutants of herpes simplex virus. Of seven mutants tested, two, carrying mutations in the immediate-early ICP4 and ICP27 proteins, were complemented. This complementation was not seen in coinfections with adenovirus type 5 or cytomegalovirus. Following transfection into CV-1 cells, a DNA fragment containing the VZV short repeat sequence complemented the ICP4 mutant. These data demonstrate a functional relationship between VZV and herpes simplex virus and have allowed localization of a putative VZV immediate-early gene.

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