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. 2018 Jan-Apr;14(1):31-35.

STATINS AND BONE HEALTH: A MINI REVIEW

Leslie R Morse  1   2 , Jennifer Coker  1 , Ricardo A Battaglino  2
Affiliations

STATINS AND BONE HEALTH: A MINI REVIEW

Leslie R Morse et al. Actual osteol. 2018 Jan-Apr.

Abstract
in English, Spanish

Statins are a widely prescribed class of medications that inhibit similar pathways as the anti-resorptive bisphosphonate drugs. Statins target the mevalonate pathway by blocking HMG-CoA reductase. Several recent meta-analyses concluded statins are osteoprotective in the general population. Here we present current literature exploring the mechanisms underlying the putative osteoprotective effects of statins. We also review recent clinical studies, ranging from observational cohort studies to randomized clinical trials, testing the effect of statins on bone health in various populations.

Las estatinas son un grupo de drogas prescriptas en forma habitual, con la capacidad de bloquear vías de señalizaciÓn similares a las inhibidas por los amino-bisfosfonatos. Las estatinas inhiben la vía del mevalonato, a través del bloqueo de diferentes enzimas. Varios metaanálisis recientes llevaron a la conclusión de que las estatinas tienen capacidad osteoprotectora en la población general. En esta revisión presentamos la literatura actual describiendo los mecanismos que subyacen en el potencial efecto osteoprotector de las estatinas, como así también estudios observacionales y clínicos aleatorizados sobre el efecto de estatinas en la salud ósea en diversas poblaciones.

Keywords: bone loss; fracture healing; statins.

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Conflict of interest statement

Disclosures All authors have no conflicts of interest.

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