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. 2018 May 17:12:49-53.
doi: 10.1016/j.jbo.2018.04.002. eCollection 2018 Sep.

Trends in incidence of Ewing sarcoma of bone in India - Evidence from the National Cancer Registry Programme (1982-2011)

Debjit Chakraborty  1 , Sukanya Rangamani  1 , Vaitheeswaran Kulothungan  1 , Meesha Chaturvedi  1 , S Stephen  1 , Priyanka Das  1 , Kondalli Lakshminarayana Sudarshan  1 , R Janani Surya  1 , K Sathish Kumar  1 , Anish John  1 , N Manoharan  2 , S S Koyande  3 , Rajaraman Swaminathan  4 , C Ramesh  5 , Atul Shrivastava  6 , B Ganesh  7 , Prashant Mathur  1 , Ambakumar Nandakumar  1
Affiliations

Trends in incidence of Ewing sarcoma of bone in India - Evidence from the National Cancer Registry Programme (1982-2011)

Debjit Chakraborty et al. J Bone Oncol. .

Abstract

Background: Ewing sarcoma is a malignant tumour found mainly in childhood and adolescence. The present study aims at analyzing the data on Ewing sarcoma cases of bone from the National Cancer Registry Programme, India to provide incidence, patterns, and trends in the Indian population.

Materials and methods: The data of five Population Based Cancer Registries (PBCR) of Bangalore, Mumbai, Chennai, Bhopal and Delhi over 30 years period (1982- 2011) were used to calculate the Age Specific and Age Standardized Incidence Rates (ASpR and ASIR), and trends in incidence was analyzed by linear and Joinpoint Regression.

Results: Ewing sarcoma comprised around 15 % of all bone malignancies. Sixty-eight percent were 0-19 years, with 1.6 times risk of tumour in bones of limbs as compared to other bones. The highest incidence rate (per million) was in the 10-14 years age group (male -4.4, female -2.9) with significantly increasing trend in ASpR observed in both sexes. Pooled ASIR per million for all ages was higher in male (1.6) than female (1.0) with an increasing rate ratio of ASIR with increase in age. Trend of pooled ASIR for all ages was significantly increased in both sexes. Twelve percent cases were reported in ≥30 years of age.

Conclusion: This paper has described population based measurements on burden and trends in incidence of skeletal Ewing in India. These may steer further research questions on the clinical and molecular epidemiology to explain factors associated with the increasing incidence of Ewing sarcoma bone observed in India.

Keywords: Bone; Cancer Registry; Ewing sarcoma; Incidence; India.

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Figures

Fig 1
Fig. 1
Comparison of Age Specific Incidence Rate (ASpR) per million of Ewing's Sarcoma of bone by age group (0–19) and sex in five PBCRs (1982–2011), India.
Fig 2
Fig. 2
Trend of Incidence Rate per million by sex in all ages (ASIR) and 10–14 years age groups (ASpR) in five PBCRs (pooled), India from 1982 to 2011.
See this image and copyright information in PMC

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