Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Sep 6:20:1305-1308.
doi: 10.1016/j.dib.2018.08.179. eCollection 2018 Oct.

Dataset on mice body weights and food intake following treatment with PG545

Affiliations

Dataset on mice body weights and food intake following treatment with PG545

Safa Kinaneh et al. Data Brief. .

Abstract

This data article contains analysis of data observed in E0 mice placed on high fat diet, and treated by intraperitoneal injections of either normal saline (control) or the heparanase inhibitor PG545, in two different doses. Mice body weights and food intake were measured weekly and analyzed data are presented in graphs. Data will be of value for further understanding the role of the enzyme heparanase in controlling food intake and body weight. For further interpretations, see please "Heparanase inhibition attenuates atherosclerosis progression and liver steatosis in E0 mice" (Muhammad et al. 2018).

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Effect of PG545 on mice body weight and food intake throughout the study in E0 mice. Weekly measurements of mice body weight (grams, A), food intake (per mouse in grams, B) and mean food intake throughout the study (grams/mouse, C). Values are presented as mean ± SEM. * Compared to control group. # Compared to PG545 low-dose group, */# p < 0.05, **/## P < 0.01, ***/### P < 0.001.

Similar articles

References

    1. Muhammad R.S., Abu-Saleh N., Kinaneh S., Agbaria M., Sabo E., Grajeda-Iglesias C., Volkova N., Hamoud S. Heparanase inhibition attenuates atherosclerosis progression and liver steatosis in E0 mice. Atherosclerosis. 2018;276:155–162. - PubMed
    1. Hamoud S., Shekh Muhammad R., Abu-Saleh N., Hassan A., Zohar Y., Hayek T. Heparanase inhibition reduces glucose levels, blood pressure, and oxidative stress in apolipoprotein E knockout mice. Biomed Res. Int. 2017;2017 - PMC - PubMed
    1. Dredge K., Hammond E., Handley P., Gonda T.J., Smith M.T., Vincent C., Brandt R., Ferro V., Bytheway I. PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. Br. J. Cancer. 2011;104:635–642. - PMC - PubMed