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Meta-Analysis
. 2019 Sep;266(9):2093-2102.
doi: 10.1007/s00415-018-9049-7. Epub 2018 Sep 20.

Prevalence of pain in atypical parkinsonism: a systematic review and meta-analysis

Abdul Qayyum Rana  1 , Abdul Rehman Qureshi  1 , Omer Siddiqui  2 , Zainab Sarfraz  1 , Ruqqiyah Rana  1 , Alexander Shtilbans  3
Affiliations
Meta-Analysis

Prevalence of pain in atypical parkinsonism: a systematic review and meta-analysis

Abdul Qayyum Rana et al. J Neurol. 2019 Sep.

Abstract

Pain is common in atypical parkinsonism such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and dementia with Lewy bodies (LBD). In this study, a systematic review and meta-analysis was conducted and peer-reviewed literature was searched to determine the prevalence and types of pain in four atypical parkinsonism syndromes: MSA, PSP, CBD and LBD. The results show that pain was prevalent mainly in MSA patients in comparison to PSP and CBD patients. Pain was reported at an early stage and was found in females, with limb pain being the most common, followed by neck and back pain. In comparison to PSP, pain locations were similar to MSA patients. CBD patients experienced pain the least in comparison to MSA, PSP and LBD patients.

Keywords: Atypical parkinsonism; Corticobasal degeneration; Dementia with Lewy bodies; Multiple system atrophy; Pain; Progressive supranuclear palsy.

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