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. 2019 Mar;11(3):422-427.
doi: 10.1002/dta.2510. Epub 2018 Oct 17.

Identification of the anabolic steroid 6β-chlorotestosterone in a dietary supplement

Travis M Falconer  1 , Rick A Flurer  1 , Mary B Jones  1 , Lisa M Lorenz  1 , Sarah E Voelker  1
Affiliations

Identification of the anabolic steroid 6β-chlorotestosterone in a dietary supplement

Travis M Falconer et al. Drug Test Anal. 2019 Mar.

Abstract

Capsules that were labeled to be performance-enhancing dietary supplements obtained during an investigation were found to contain an unrecognized steroid-like substance. This compound was isolated by liquid chromatography (LC) fraction collection and characterized using several qualitative analytical techniques, including ultraviolet (UV) spectroscopy, gas chromatography-mass spectrometry (GC-MS), liquid chromatography-high resolution accurate mass-mass spectrometry (LC-HRAM-MS), as well as 1 H, 13 C, and two-dimensional nuclear magnetic resonance (NMR) spectrometry. This multi-technique analytical approach was used to identify the designer steroid as 6β-chloro-4-androsten-17β-ol-3-one (6β-chlorotestosterone), an analog of testosterone about which little has been published.

Keywords: NMR; dietary supplement; mass spectrometry; spectroscopy; steroid.

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