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. 1986 Jun;6(6):2106-14.
doi: 10.1128/mcb.6.6.2106-2114.1986.

Multiple regulation of STE2, a mating-type-specific gene of Saccharomyces cerevisiae

A Hartig, J Holly, G Saari, V L MacKay

Multiple regulation of STE2, a mating-type-specific gene of Saccharomyces cerevisiae

A Hartig et al. Mol Cell Biol. 1986 Jun.

Abstract

The Saccharomyces cerevisiae STE2 gene, which is required for pheromone response and conjugation specifically in mating-type a cells, was cloned by complementation of the ste2 mutation. Transcription of STE2 is repressed by the MAT alpha 2 gene product, so that the 1.4-kilobase STE2 RNA is detected only in a or mat alpha 2 strains, not in alpha or a/alpha cells. However, STE2 RNA levels are also increased by the mating pheromone alpha-factor and decreased in strains bearing mutations in the nonspecific STE4 gene. Regulation of STE2 expression in a cells is therefore achieved by several mechanisms.

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