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. 2019 May 17;68(11):1831-1838.
doi: 10.1093/cid/ciy800.

Decline in Pneumococcal Disease Attenuated in Older Adults and Those With Comorbidities Following Universal Childhood PCV13 Immunization

Stephen I Pelton  1   2 , Rebecca Bornheimer  3 , Robin Doroff  3 , Kimberly M Shea  1 , Reiko Sato  4 , Derek Weycker  3
Affiliations

Decline in Pneumococcal Disease Attenuated in Older Adults and Those With Comorbidities Following Universal Childhood PCV13 Immunization

Stephen I Pelton et al. Clin Infect Dis. .

Abstract

Background: Following introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in the United States, epidemiology of pneumococcal disease shifted such that disease incidence in the elderly exceeded that in children. We evaluated the impact of replacing PCV7 with PCV13 on disease burden in adults and identified age/risk-specific subgroups with the highest remaining disease burden.

Methods: A retrospective design and data from two US healthcare claims repositories were used. Study population included adults aged ≥18 years and was stratified by age (18-49, 50-64, 65-74, ≥75) and risk profile (healthy, at-risk, high-risk). Rate ratios comparing invasive pneumococcal disease (IPD), all-cause hospitalized pneumonia (ACHP), and pneumococcal pneumonia requiring hospitalization among at-risk and high-risk adults vs healthy counterparts were estimated for 2007-2010 (pre-PCV13), 2011-2012 (peri-PCV13), and 2013-2015 (post-PCV13).

Results: Across study periods, IPD and ACHP rates increased with age (2-27 times higher in persons ≥75 vs 18-49) and comorbidity (4-20 times higher in high-risk vs healthy). From pre- to post-PCV13 period, IPD rates declined 5%-48% and ACHP rates declined 4%-19% across age and risk groups (ACHP did not decline in persons ≥75). Decline in IPD and ACHP was attenuated among older adults and those with comorbidities. Accordingly, rate ratios among at-risk and high-risk persons (vs healthy counterparts) increased during the peri- and post-PCV13 periods compared with the pre-PCV13 period.

Conclusions: The switch to PCV13 was associated with large declines in pneumococcal disease among US adults. However, the decline was attenuated with increasing age (and, for ACHP, was absent in persons ≥75) and in those with comorbidities.

Keywords: Streptococcus pneumonia; comorbidity; immunocompromised; pneumococcal infections; pneumonia.

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Figures

Figure 1.
Figure 1.
Distribution of episodes of invasive pneumococcal disease requiring hospitalization by risk profile in 2007–2010, 2011–2012, and 2013–2015, by age. Abbreviation: IPD, invasive pneumococcal disease.
Figure 2.
Figure 2.
Distribution of episodes of all-cause pneumonia requiring hospitalization by risk profile in 2007–2010, 2011–2012, and 2013–2015, by age. Abbreviation: PNE, all-cause pneumonia.
See this image and copyright information in PMC

References

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