Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2018 Oct;8(10):e01115.
doi: 10.1002/brb3.1115. Epub 2018 Sep 21.

Association of neurofascin IgG4 and atypical chronic inflammatory demyelinating polyneuropathy: A systematic review and meta-analysis

Wenyu Hu  1 , Yanguo Xin  1 , Zhiyi He  2 , Yinan Zhao  2
Affiliations
Meta-Analysis

Association of neurofascin IgG4 and atypical chronic inflammatory demyelinating polyneuropathy: A systematic review and meta-analysis

Wenyu Hu et al. Brain Behav. 2018 Oct.

Abstract

Background: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most commonly observed phenotype among chronic acquired demyelinating polyneuropathies and is clinically variable. The aim of this meta-analysis was to evaluate the diagnostic value and characteristics of CIDP targeting neurofascin 155 (NF155).

Methods: A systematic literature search was performed on March 2018, and two reviewers independently extracted data and assessed the risk of bias on MEDLINE, EMBASE, the Web of Science, and the Cochrane Library to identify relevant articles.

Results: Ten articles for the NF155 protein test with 1,161 patients and 1,636 controls were identified. The results showed that the pooled sensitivity was 0.09 (95% CI: 0.06-015), and specificity was 1.00 (95% CI: 0.98-1.00) of the NF155 for CIDP. The meta-analysis revealed that the sensory ataxic occurrence rate (OR: 10.79, 95% CI: 5.24-22.22) and tremor occurrence rate (OR: 6.71, 95% CI: 3.37-13.39) were higher among patients positive for NF155 compared with NF155-negative CIDP patients. However, the rate of good treatment response to intravenous immunoglobulin (IVIg) (OR: 0.09, 95% CI: 0.02-0.42) was lower in NF155-positive CIDP patients.

Conclusions: NF155 is a specific protein marker for CIDP, but its diagnostic value has been questioned due to low sensitivity. However, as an antibody against paranodal antigens, NF155 seems more valuable in defining clinical subsets of CIDP.

Keywords: NF155; chronic inflammatory demyelinating polyradiculoneuropathy; diagnosis; meta-analysis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flowchart of study selection
Figure 2
Figure 2
Forest plots of sensitivity and specificity for NF155 in CIDP patients
Figure 3
Figure 3
Post‐test probabilities of NF155 versus prior probabilities using summary likelihood ratios in CIDP
Figure 4
Figure 4
Summary receiver operating characteristics of NF155 in CIDP
Figure 5
Figure 5
Publication bias test of the diagnostic meta‐analysis
Figure 6
Figure 6
Forest plots of weighted mean difference (WMD) in NF155‐positive CIDP group and NF155‐negative CIDP group for clinical features. Horizontal lines are 95% confidence intervals
See this image and copyright information in PMC

References

    1. Burnor, E. , Yang, L. , Zhou, H. , Patterson, K. R. , Quinn, C. , Reilly, M. M. , … Lancaster, E. (2018). Neurofascin antibodies in autoimmune, genetic, and idiopathic neuropathies. Neurology, 90, e31–e38. 10.1212/WNL.0000000000004773. - DOI - PMC - PubMed
    1. Charles, P., Tait, S., Faivre‐Sarrailh, C., Barbin, G., Gunn‐Moore, F., Denisenko‐Nehrbass, N., …Lubetzki, C. (2002). Neurofascin is a glial receptor for the paranodin/Caspr‐contactin axonal complex at the axoglial junction. Current Biology, 12, 217–220. 10.1016/S0960-9822(01)00680-7. - DOI - PubMed
    1. Davis, J. Q. (1996). Molecular composition of the node of Ranvier: Identification of ankyrin‐ binding cell adhesion molecules neurofascin (mucin+/third FNIII domain‐ ) and NrCAM at nodal axon segments. The Journal of Cell Biology, 135, 1355–1367. 10.1083/jcb.135.5.1355. - DOI - PMC - PubMed
    1. Delmont, E. , Manso, C. , Querol, L. , Cortese, A. , Berardinelli, A. , Lozza, A. , … Devaux, J. J. (2017). Autoantibodies to nodal isoforms of neurofascin in chronic inflammatory demyelinating polyneuropathy. Brain, 140, 1851–1858. 10.1093/brain/awx124. - DOI - PubMed
    1. Devaux, J. J. (2012). Antibodies to gliomedin cause peripheral demyelinating neuropathy and the dismantling of the nodes of Ranvier. American Journal of Pathology, 181, 1402–1413. 10.1016/j.ajpath.2012.06.034. - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources