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. 1986 Nov 11;14(21):8373-86.
doi: 10.1093/nar/14.21.8373.

Genomic localization of hepatitis B virus in a human hepatoma cell line

M Zerial, J Salinas, J Filipski, G Bernardi
Free PMC article

Genomic localization of hepatitis B virus in a human hepatoma cell line

M Zerial et al. Nucleic Acids Res. .
Free PMC article

Abstract

The integration of hepatitis B viral sequences in the human hepatoma Alexander cell line has been investigated after fractionation of the cell line DNA by centrifugation in a Cs2SO4/BAMD (3,6-(bis-acetato mercurimethyl) dioxane) density gradient. Eight out of nine integrated viral sequences were localized in DNA component H3, which only represents 4% of the human genome and matches the base composition of HBV sequences. These results indicate a targeting and/or a higher stability of the latter in a specific, small compartment of the host genome.

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References

    1. S Afr Med J. 1976 Dec 18;50(54):2124-8 - PubMed
    1. Nature. 1986 Jul 3-9;322(6074):70-2 - PubMed
    1. J Mol Biol. 1977 Jun 15;113(1):237-51 - PubMed
    1. Eur J Biochem. 1978 Mar;84(1):179-88 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Oct;76(10):4822-6 - PubMed

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