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. 2019 Apr;64(4):467-471.
doi: 10.1016/j.jadohealth.2018.07.006. Epub 2018 Sep 18.

Minority Stress Factors Associated With Depression and Anxiety Among Transgender and Gender-Nonconforming Youth

Affiliations

Minority Stress Factors Associated With Depression and Anxiety Among Transgender and Gender-Nonconforming Youth

Gia Chodzen et al. J Adolesc Health. 2019 Apr.

Abstract

Purpose: Transgender and gender-nonconforming (TGNC) adolescents and young adults experience mental health problems, including anxiety and depression, at an elevated rate as compared to their cisgender counterparts. A growing literature suggests that vulnerability to psychiatric problems in TGNC individuals results from social discrimination and minority stress.

Methods: The sample consisted of adolescent TGNC patients (N = 109) who completed behavior health screening questionnaires as standard of care at their first clinical visit to an interdisciplinary gender program within a pediatric academic medical center in a metropolitan Midwestern city. Binary logistic regressions were used to assess whether the likelihood that participants met clinical diagnostic criteria for Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) was predicted by gender identity appearance congruence, proximal forms of minority stress (e.g., negative expectations of the future related to gender identity; internalized transphobia) and community connectedness (i.e., resilience) .

Results: Overall, 33% (n = 36) of the sample met diagnostic criteria for MDD and 48% (n = 53) met diagnostic criteria for GAD. Those with high levels of internalized transphobia were significantly more likely to meet diagnostic criteria for both MDD and GAD. Those with low levels of gender identity appearance congruence were significantly more likely to meet diagnostic criteria for MDD but not GAD.

Conclusion: There are several unique factors that may predict mental illness among TGNC youth. Understanding these factors may offer opportunities for targeted clinical and structural interventions.

Keywords: Adolescents; Anxiety; Depression; Gender-nonconforming; Health disparity; Minority stress; Transgender.

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Conflict of interest statement

Conflicts of interest: The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Visual depiction of the model tested in the present study

References

    1. Connolly MD, Zervos MJ, Barone CJ, Johnson CC, Joseph CLM. The mental health of transgender youth: Advances in understanding. J Adolesc Health 2016;59:489–95. - PubMed
    1. Reisner SL, Vetters R, Leclerc M, et al. Mental health of transgender youth in care at an adolescent urban community health center: A matched retrospective cohort study. J Adolesc Health 2015;56:274–9. - PMC - PubMed
    1. Olson J, Schrager SM, Simons LK, Clark LF. Baseline physiologic and psychosocial characteristics of transgender youth seeking care for gender dysphoria. J Adolesc Health 2015;57:374–80. - PMC - PubMed
    1. de Vries ALC, Doreleijers TAH, Steensma TD, Cohen-Kettenis PT. Psychiatric comorbidity in gender dysphoric adolescents. J Child Psychol Psychiatry 2011;52:1195–202. - PubMed
    1. Center for Behavioral Health Statistics and Quality Key substance use and mental health indicators in the United States: Results from the 2015 National Survey on Drug Use and Health. Rockville, MD: Substance Abuse and Mental Health Services Administration, 2016.

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