AAV Immunogenicity: A Matter of Sensitivity
- PMID: 30241741
- PMCID: PMC6171166
- DOI: 10.1016/j.ymthe.2018.09.001
AAV Immunogenicity: A Matter of Sensitivity
Comment on
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Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates.Nat Med. 2017 Apr;23(4):439-449. doi: 10.1038/nm.4290. Epub 2017 Feb 20. Nat Med. 2017. PMID: 28218919
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Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4.Nat Med. 2017 Jun;23(6):742-752. doi: 10.1038/nm.4334. Epub 2017 May 8. Nat Med. 2017. PMID: 28481357
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The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis.Nat Med. 2018 Jan;24(1):84-94. doi: 10.1038/nm.4453. Epub 2017 Dec 11. Nat Med. 2018. PMID: 29227477
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The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.Nat Med. 2018 Feb;24(2):213-223. doi: 10.1038/nm.4461. Epub 2018 Jan 1. Nat Med. 2018. PMID: 29291351
References
-
- Mingozzi F., High K.A. Overcoming the Host Immune Response to Adeno-Associated Virus Gene Delivery Vectors: The Race Between Clearance, Tolerance, Neutralization, and Escape. Annu. Rev. Virol. 2017;4:511–534. - PubMed
-
- Jiang H., Couto L.B., Patarroyo-White S., Liu T., Nagy D., Vargas J.A., Zhou S., Scallan C.D., Sommer J., Vijay S. Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy. Blood. 2006;108:3321–3328. - PMC - PubMed
-
- Ji Y.X., Huang Z., Yang X., Wang X., Zhao L.P., Wang P.X., Zhang X.J., Alves-Bezerra M., Cai L., Zhang P. The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Nat. Med. 2018;24:213–223. - PubMed
-
- Zhang P., Wang P.X., Zhao L.P., Zhang X., Ji Y.X., Zhang X.J., Fang C., Lu Y.X., Yang X., Gao M.M. The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis. Nat. Med. 2018;24:84–94. - PubMed
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- Zhao G.N., Zhang P., Gong J., Zhang X.J., Wang P.X., Yin M., Jiang Z., Shen L.J., Ji Y.X., Tong J. Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4. Nat. Med. 2017;23:742–752. - PubMed
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