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Comment
. 2018 Oct 3;26(10):2335-2336.
doi: 10.1016/j.ymthe.2018.09.001. Epub 2018 Sep 18.

AAV Immunogenicity: A Matter of Sensitivity

Affiliations
Comment

AAV Immunogenicity: A Matter of Sensitivity

Federico Mingozzi. Mol Ther. .
No abstract available

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References

    1. Mingozzi F., High K.A. Overcoming the Host Immune Response to Adeno-Associated Virus Gene Delivery Vectors: The Race Between Clearance, Tolerance, Neutralization, and Escape. Annu. Rev. Virol. 2017;4:511–534. - PubMed
    1. Jiang H., Couto L.B., Patarroyo-White S., Liu T., Nagy D., Vargas J.A., Zhou S., Scallan C.D., Sommer J., Vijay S. Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy. Blood. 2006;108:3321–3328. - PMC - PubMed
    1. Ji Y.X., Huang Z., Yang X., Wang X., Zhao L.P., Wang P.X., Zhang X.J., Alves-Bezerra M., Cai L., Zhang P. The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Nat. Med. 2018;24:213–223. - PubMed
    1. Zhang P., Wang P.X., Zhao L.P., Zhang X., Ji Y.X., Zhang X.J., Fang C., Lu Y.X., Yang X., Gao M.M. The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis. Nat. Med. 2018;24:84–94. - PubMed
    1. Zhao G.N., Zhang P., Gong J., Zhang X.J., Wang P.X., Yin M., Jiang Z., Shen L.J., Ji Y.X., Tong J. Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4. Nat. Med. 2017;23:742–752. - PubMed

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