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. 1986;90(2):268-9.
doi: 10.1007/BF00181255.

Increased central alpha 2-adrenoceptor sensitivity in panic disorder

D J Nutt

Increased central alpha 2-adrenoceptor sensitivity in panic disorder

D J Nutt. Psychopharmacology (Berl). 1986.

Abstract

Cardiovascular responses to an intravenous challenge dose of clonidine (1.5 micrograms/kg) were measured in eight patients with DSM III panic disorder. In comparison with an age- and sex-matched control population panic patients showed significantly greater falls in systolic and diastolic blood pressure, with similar falls in heart rate. These observations support the view of a biological abnormality in panic disorder.

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