Stress-inducible-stem cells: a new view on endocrine, metabolic and mental disease?

S R Bornstein^{1

2

3

4

5}, C Steenblock⁶, G P Chrousos⁷, A V Schally^{8

9}, F Beuschlein^{10

11}, G Kline¹², N P Krone^{13

14}, J Licinio^{15

16}, M L Wong^{15

16}, E Ullmann^{6

17}, G Ruiz-Babot^{6

18}, B O Boehm¹⁹, A Behrens²⁰, A Brennand^{6

21}, A Santambrogio^{6

22}, I Berger⁶, M Werdermann⁶, R Sancho²³, A Linkermann⁶, J W Lenders^{6

24}, G Eisenhofer⁶, C L Andoniadou^{6

22}

Affiliations

¹ University Hospital Carl Gustav Carus, Department of Medicine III, Technische Universität Dresden, Dresden, Germany. stefan.bornstein@uniklinikum-dresden.de.
² Diabetes and Nutritional Sciences, King's College London, London, UK. stefan.bornstein@uniklinikum-dresden.de.
³ Center for Regenerative Therapies, Technische Universität Dresden, Dresden, Germany. stefan.bornstein@uniklinikum-dresden.de.
⁴ Paul Langerhans Institute Dresden of Helmholtz Centre Munich at University Clinic Carl Gustav Carus of TU Dresden Faculty of Medicine, Dresden, Germany. stefan.bornstein@uniklinikum-dresden.de.
⁵ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. stefan.bornstein@uniklinikum-dresden.de.
⁶ University Hospital Carl Gustav Carus, Department of Medicine III, Technische Universität Dresden, Dresden, Germany.
⁷ Center for Adolescent Medicine, UNESCO Chair on Adolescent Health Care, First Department of Pediatrics, Kapodistrian University of Athens, Aghia Sophia Children's Hospital, Athens, Greece.
⁸ Divisions of Endocrinology and Hematology-Oncology, Departments of Medicine and Department of Pathology, University of Miami, Miller School of Medicine, Miami, FL, USA.
⁹ Veterans Affairs Medical Center, Miami, FL, USA.
¹⁰ Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany.
¹¹ Klinik für EndokrinologieDiabetologie und Klinische Ernährung, UniversitätsSpital Zürich, Zürich, Switzerland.
¹² Division of Endocrinology and Metabolism, Department of Medicine, University of Calgary, Calgary, Alta, Canada.
¹³ Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
¹⁴ Department of Endocrinology, Sheffield Children's NHS Foundation Trust, Sheffield, UK.
¹⁵ Department of Psychiatry, College of Medicine, State University of New York, Upstate Medical University, Syracuse, NY, USA.
¹⁶ Departments of Pharmacology and Medicine, College of Medicine, State University of New York, Upstate Medical University, Syracuse, NY, USA.
¹⁷ Department for Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Leipzig, Leipzig, Germany.
¹⁸ Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
¹⁹ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
²⁰ Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.
²¹ Diabetes and Nutritional Sciences, King's College London, London, UK.
²² Centre for Craniofacial and Regenerative Biology, King's College London, London, UK.
²³ Centre for Stem Cells and Regenerative Medicine, King's College London, London, UK.
²⁴ Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.

PMID: 30242231
PMCID: PMC6755998
DOI: 10.1038/s41380-018-0244-9

Editorial

Stress-inducible-stem cells: a new view on endocrine, metabolic and mental disease?

S R Bornstein et al. Mol Psychiatry. 2019 Jan.

. 2019 Jan;24(1):2-9.

doi: 10.1038/s41380-018-0244-9. Epub 2018 Sep 21.

Authors

Affiliations

¹ University Hospital Carl Gustav Carus, Department of Medicine III, Technische Universität Dresden, Dresden, Germany. stefan.bornstein@uniklinikum-dresden.de.
² Diabetes and Nutritional Sciences, King's College London, London, UK. stefan.bornstein@uniklinikum-dresden.de.
³ Center for Regenerative Therapies, Technische Universität Dresden, Dresden, Germany. stefan.bornstein@uniklinikum-dresden.de.
⁴ Paul Langerhans Institute Dresden of Helmholtz Centre Munich at University Clinic Carl Gustav Carus of TU Dresden Faculty of Medicine, Dresden, Germany. stefan.bornstein@uniklinikum-dresden.de.
⁵ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. stefan.bornstein@uniklinikum-dresden.de.
⁶ University Hospital Carl Gustav Carus, Department of Medicine III, Technische Universität Dresden, Dresden, Germany.
⁷ Center for Adolescent Medicine, UNESCO Chair on Adolescent Health Care, First Department of Pediatrics, Kapodistrian University of Athens, Aghia Sophia Children's Hospital, Athens, Greece.
⁸ Divisions of Endocrinology and Hematology-Oncology, Departments of Medicine and Department of Pathology, University of Miami, Miller School of Medicine, Miami, FL, USA.
⁹ Veterans Affairs Medical Center, Miami, FL, USA.
¹⁰ Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany.
¹¹ Klinik für EndokrinologieDiabetologie und Klinische Ernährung, UniversitätsSpital Zürich, Zürich, Switzerland.
¹² Division of Endocrinology and Metabolism, Department of Medicine, University of Calgary, Calgary, Alta, Canada.
¹³ Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
¹⁴ Department of Endocrinology, Sheffield Children's NHS Foundation Trust, Sheffield, UK.
¹⁵ Department of Psychiatry, College of Medicine, State University of New York, Upstate Medical University, Syracuse, NY, USA.
¹⁶ Departments of Pharmacology and Medicine, College of Medicine, State University of New York, Upstate Medical University, Syracuse, NY, USA.
¹⁷ Department for Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Leipzig, Leipzig, Germany.
¹⁸ Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
¹⁹ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
²⁰ Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK.
²¹ Diabetes and Nutritional Sciences, King's College London, London, UK.
²² Centre for Craniofacial and Regenerative Biology, King's College London, London, UK.
²³ Centre for Stem Cells and Regenerative Medicine, King's College London, London, UK.
²⁴ Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.

PMID: 30242231
PMCID: PMC6755998
DOI: 10.1038/s41380-018-0244-9

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

**Fig. 1**
Stem cells from a range of tissues are influenced by different kinds of stress in both a positive (eustress) and negative (distress) manner giving rise to positive/negative metabolic memory

See this image and copyright information in PMC

References

1. Selye H. In Stress without distress. J.B. Lippincott Co: Philadelphia, PA. 1974.
1. Selye H. In Stress in health and disease. Butterworth Inc; Boston, MA. 1976:928–1148.
1. Selye H. A syndrome produced by diverse nocuous agents. 1936. J Neuropsychiatry Clin Neurosci. 1998;10:230–1. doi: 10.1176/jnp.10.2.230a. - DOI - PubMed
1. Chrousos GP, Gold PW. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA. 1992;267:1244–52. doi: 10.1001/jama.1992.03480090092034. - DOI - PubMed
1. Nicolaides NC, Kyratzi E, Lamprokostopoulou A, Chrousos GP, Charmandari E. Stress, the stress system and the role of glucocorticoids. Neuroimmunomodulation. 2015;22:6–19. doi: 10.1159/000362736. - DOI - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Stress-inducible-stem cells: a new view on endocrine, metabolic and mental disease?

Affiliations

Stress-inducible-stem cells: a new view on endocrine, metabolic and mental disease?

Authors

Affiliations

Conflict of interest statement

Figures

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical