A new BEACON of hope for the treatment of inflammation? The endogenous metabolite itaconate as an alternative activator of the KEAP1-Nrf2 system

Affiliations

¹ IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.
² Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
³ IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy. Electronic address: ariela.benigni@marionegri.it.

Free article

Comment

Luca Perico et al. Kidney Int. 2018 Oct.

Free article

. 2018 Oct;94(4):646-649.

doi: 10.1016/j.kint.2018.07.018.

¹ IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.
² Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
³ IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy. Electronic address: ariela.benigni@marionegri.it.

No abstract available

Keywords: inflammation; ischemia reperfusion; macrophages; oxidative stress.

Comment on

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.