doi: 10.1007/978-1-4939-8802-0_2.
Human Xenograft Model
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- PMID: 30244449
- DOI: 10.1007/978-1-4939-8802-0_2
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Human Xenograft Model
Methods Mol Biol.
2018.
Abstract
Human-SCID grafting is a commonly used technique for the long-term investigation of rheumatoid arthritis (RA) explants. To establish a chimeric immunological system in NOD/SCID mice, RA patient-derived pannus tissue from the synovial membrane, articular cartilage, and bone can be transplanted subcutaneously. The same patient-derived peripheral blood mononuclear cell chimerism can be successfully achieved by intraperitoneal engraftment. This xenograft model is able to be used for initial screening of human target-specified biologics.
Keywords: Articular tissue; NOD/SCID mouse; Peripheral blood mononuclear cell; Synovial invasion; Xenograft rheumatoid arthritis model.
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