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Case Reports
. 2018 Sep 14;4(8):808-810.
doi: 10.1016/j.jdcr.2018.06.025. eCollection 2018 Sep.

Palisaded neutrophilic and granulomatous dermatitis associated with ledipasvir/sofosbuvir

Mary Elizabeth Reed Shenk  1 , Kimberly Marie Ken  1 , Kara Braudis  1 , Kristen Heins Fernandez  1
Affiliations
Case Reports

Palisaded neutrophilic and granulomatous dermatitis associated with ledipasvir/sofosbuvir

Mary Elizabeth Reed Shenk et al. JAAD Case Rep. .
No abstract available

Keywords: GA, granuloma annulare; HCV, hepatitis C virus; INF, interferon; LDV/SOF, ledipasvir/sofosbuvir; PNGD, palisaded neutrophilic and granulomatous dermatitis; drug reaction; granulomatous dermatitis; hepatitis C; ledipasvir/sofosbuvir; palisaded neutrophilic and granulomatous dermatitis.

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Figures

Fig 1
Fig 1
A, PNGD: Multiple erythematous nodules on the palm. B, PNGD: Erythematous nodules on the right lateral digit and palm.
Fig 2
Fig 2
A, PNGD: Nodular and palisaded collections of histiocytes with multinucleated histiocytes and associated lymphocytes. B, PNGD: Scattered mononuclear cells within areas of granulomatous infiltration. (A, Hematoxylin-eosin stain; B, Myeloperoxidase stain; original magnifications: A, ×10; B, ×4.)
See this image and copyright information in PMC

References

    1. Rosenbach M., English J.C., 3rd Reactive granulomatous dermatitis: a review of palisaded neutrophilic and granulomatous dermatitis, interstitial granulomatous dermatitis, interstitial granulomatous drug reaction, and a proposed reclassification. Dermatol Clin. 2015;33(3):373–387. - PubMed
    1. Kalen J.E., Shokeen D., Ramos-Caro F., Motaparthi K. Palisaded neutrophilic granulomatous dermatitis: spectrum of histologic findings in a single patient. JAAD Case Rep. 2017;3(5):425–428. - PMC - PubMed
    1. Johnson S.W., Ammirati S.R., Hartis C.E. Effectiveness of ledipasvir/sofosbuvir in real-world patients with chronic hepatitis C: a collaborative treatment approach. Int J Antimicrob Agents. 2017;49(6):778–781. - PubMed
    1. Afdhal N., Zeuzem S., Kwo P. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Eng J Med. 2014;370(20):1889–1898. - PubMed
    1. Gordon K., Miteva M., Torchia D., Romanelli P. Allopurinol-induced palisaded neutrophilic and granulomatous dermatitis. Cutan Ocul Toxicol. 2012;31(4):338–340. - PubMed

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