Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms

Eric Baudin¹, Aimee R Hayes², Jean-Yves Scoazec³, Pier Luigi Filosso⁴, Eric Lim⁵, Gregory Kaltsas⁶, Andrea Frilling⁷, Jie Chen⁸, Beata Kos-Kudła⁹, Vera Gorbunova¹⁰, Bertram Wiedenmann¹¹, Els Nieveen van Dijkum¹², Jaroslaw B Ćwikła¹³, Jenny Falkerby¹⁴, Juan W Valle¹⁵, Matthew H Kulke¹⁶, Martyn E Caplin¹⁷; ENETS 2016 Munich Advisory Board Participants; ENETS 2016 Munich Advisory Board Participants

Collaborators, Affiliations

Collaborators

Detlef Bartsch¹⁸, Rudolf Arnold¹⁹, Eric Baudin²⁰, Lisa Bodei²¹, Ivan Borbath²², Jaume Capdevila²³, Martyn Caplin²⁴, Jie Chen²⁵, Frederico Costa²⁶, Anne Couvelard²⁷, Jaroslaw Ćwikła²⁸, Philippa Davies, Herder de²⁹, Massimo Falconi³⁰, Jenny Falkerby³¹, Nicola Fazio³², Diego Ferone³³, Andrea Frilling³⁴, Rocio Garcia-Carbonero³⁵, Simona Glasberg, Vera Gorbunova, Ashley Grossman³⁶, Dieter Hörsch³⁷, Robert Jensen³⁸, Gregory Kaltsas³⁹, Günter Klöppel⁴⁰, Ulrich Knigge⁴¹, Beata Kos-Kudła⁴², Guenter Krejs⁴³, Eric Krenning⁴⁴, Matthew Kulke⁴⁵, Steven Lamberts, van Nieveen⁴⁶, Juan O'Connor⁴⁷, Dermot O'Toole⁴⁸, Ulrich-Frank Pape⁴⁹, Stefano Partelli⁵⁰, Marianne Pavel⁵¹, Marc Peeters⁵², John Ramage⁵³, Nicholas Reed⁵⁴, Guido Rindi⁵⁵, Anja Rinke⁵⁶, Philippe Ruszniewski⁵⁷, Halfdan Sorbye⁵⁸, Anders Sundin⁵⁹, Jean-Yves Scoazec⁶⁰, Babs Taal⁶¹, Janson Tiensuu⁶², Christos Toumpanakis³⁶, Juan Valle⁶³, Marie-Pierre Vullierme⁶⁴, Staffan Welin⁶⁵, Bertram Wiedenmann⁶⁶

Affiliations

¹ Oncologie Endocrinienne et Médecine Nucléaire, Institut Gustave Roussy, Villejuif, France.
² Neuroendocrine Tumour Unit, Royal Free Hospital, London, United Kingdom.
³ Department of Pathology, University of Lyon, Lyon, France.
⁴ Department of Thoracic Surgery, University of Torino, Torino, Italy.
⁵ Department of Thoracic Surgery, Royal Brompton Hospital, London, United Kingdom.
⁶ Department of Pathophysiology, Division of Endocrinology, National University of Athens, Athens, Greece.
⁷ Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
⁸ Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
⁹ Slaska Akademia Medyczna Klinika Endokrynologii, Zabrze, Poland.
¹⁰ FSBI "N.N Blokhin Russian Cancer Research Centre," Russian Academy of Medical Sciences, Moscow, Russian Federation.
¹¹ Department of Hepatology and Gastroenterology, Campus Charité Mitte and Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, Berlin, Germany.
¹² Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands.
¹³ Department of Radiology, Faculty of Medical Sciences, University of Warmia and Mazury, Olsztyn, Poland.
¹⁴ Department of Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden.
¹⁵ Department of Medical Oncology, The Christie NHS Foundation Trust, University of Manchester/Institute of Cancer Sciences, Manchester, United Kingdom.
¹⁶ Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
¹⁷ Neuroendocrine Tumour Unit, Royal Free Hospital, London, United Kingdomm.caplin@ucl.ac.uk.
¹⁸ UKGM GmbH, Marburg, Germany.
¹⁹ University Hospital, Marburg, Germany.
²⁰ Institut Gustave, Roussy, France.
²¹ Memorial Sloan Kettering Cancer Center, USA.
²² Cliniques universitaires, Saint-Luc, Belgium.
²³ Vall d'Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Spain.
²⁴ Department of Medicine, Royal Free Hospital, UK.
²⁵ The First Affiliated Hospital, Sun Yat-Sen University, China.
²⁶ Oncoclin Medicos Associados S/S Ltda. c/o Frederico Costa - Regina Lima, Brazil.
²⁷ Hôpital Bichat, Service de Pathologie, France.
²⁸ Department of Radiology, Faculty of Medical Sciences, Univeristy of Warmia and Mazury, Poland.
²⁹ Erasmus MC, Department of Internal Medicine, Section of Endocrinology, The Netherlands.
³⁰ Department of Surgery, Università Vita e Salute, Italy.
³¹ Department of Endocrine Oncology, Uppsala University Hospital, Sweden.
³² European Institute of Oncology, Italy.
³³ University of Genova, Italy.
³⁴ Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, UK.
³⁵ Hospital Universitario Doce de Octubre, Spain.
³⁶ Royal Free Hospital, London, UK.
³⁷ Zentralklinik Bad Berka GmbH, CA Gastroenterologie, Germany.
³⁸ National Institutes of Health, USA.
³⁹ Endocrine Unit, Department of Pathophysiology, National University of Athens, Greece.
⁴⁰ Consultation Center for Pancreatic and Endocrine Tumors/Department of Pathology/TU-Munich, Germany.
⁴¹ Rigshospitalet, Department of Surgery (C2122), Denmark.
⁴² Department of Endocrinology and Neuroendocrine Tumors, Medical University of Silesia, Poland.
⁴³ Universitätsklinik für Innere Medizin, Austria.
⁴⁴ Erasmus MC, The Netherlands.
⁴⁵ Dana-Farber Cancer Institute, USA.
⁴⁶ Amsterdam Working Hospital, The Netherlands.
⁴⁷ Instituto Fleming, Argentina.
⁴⁸ St. James's and St Vincnt's Univerrsity Hospitals and Trinity College Dublin, Ireland.
⁴⁹ Charité Campus Mitte, Berlin, Germany.
⁵⁰ Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, "Vita-Salute" University, Milan, Italy.
⁵¹ Universitätsklinikum Erlangen, Germany.
⁵² Department of Oncology, Antwerp University Hospital, Belgium.
⁵³ Hampshire Hospitals NHS Trust, UK.
⁵⁴ Beatson Oncology Centre/Gartnavel General Hospital, UK.
⁵⁵ Policlinico Universitario A. Gemelli, Rome, Italy.
⁵⁶ Uniklinikum Giessen und Marburg, Germany.
⁵⁷ Department of Gastroenterology-Pancreatology, Beaujon Hospital, France.
⁵⁸ Haukeland University Hospital, Department of Oncology, Norway.
⁵⁹ Department of Radiology, Institute of Surgical Sciences, Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden.
⁶⁰ Gustave Roussy, Biopathology, France.
⁶¹ Netherlands Cancer Centre, The Netherlands.
⁶² Uppsala University, Sweden.
⁶³ University of Manchester/The Christie NHS Foundation Trust, UK.
⁶⁴ Hôpital Beaujon - Radiologie, France.
⁶⁵ Endocrine Oncology, University Hospital, Uppsala, Sweden.
⁶⁶ Gastroenterology, Charité Medical School and Hospital (Virchow), Germany.

PMID: 30248673
DOI: 10.1159/000493980

Free article

Review

Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms

Eric Baudin et al. Neuroendocrinology. 2019.

Free article

. 2019;108(1):7-17.

doi: 10.1159/000493980. Epub 2018 Sep 24.

Authors

Collaborators

Detlef Bartsch¹⁸, Rudolf Arnold¹⁹, Eric Baudin²⁰, Lisa Bodei²¹, Ivan Borbath²², Jaume Capdevila²³, Martyn Caplin²⁴, Jie Chen²⁵, Frederico Costa²⁶, Anne Couvelard²⁷, Jaroslaw Ćwikła²⁸, Philippa Davies, Herder de²⁹, Massimo Falconi³⁰, Jenny Falkerby³¹, Nicola Fazio³², Diego Ferone³³, Andrea Frilling³⁴, Rocio Garcia-Carbonero³⁵, Simona Glasberg, Vera Gorbunova, Ashley Grossman³⁶, Dieter Hörsch³⁷, Robert Jensen³⁸, Gregory Kaltsas³⁹, Günter Klöppel⁴⁰, Ulrich Knigge⁴¹, Beata Kos-Kudła⁴², Guenter Krejs⁴³, Eric Krenning⁴⁴, Matthew Kulke⁴⁵, Steven Lamberts, van Nieveen⁴⁶, Juan O'Connor⁴⁷, Dermot O'Toole⁴⁸, Ulrich-Frank Pape⁴⁹, Stefano Partelli⁵⁰, Marianne Pavel⁵¹, Marc Peeters⁵², John Ramage⁵³, Nicholas Reed⁵⁴, Guido Rindi⁵⁵, Anja Rinke⁵⁶, Philippe Ruszniewski⁵⁷, Halfdan Sorbye⁵⁸, Anders Sundin⁵⁹, Jean-Yves Scoazec⁶⁰, Babs Taal⁶¹, Janson Tiensuu⁶², Christos Toumpanakis³⁶, Juan Valle⁶³, Marie-Pierre Vullierme⁶⁴, Staffan Welin⁶⁵, Bertram Wiedenmann⁶⁶

Affiliations

¹ Oncologie Endocrinienne et Médecine Nucléaire, Institut Gustave Roussy, Villejuif, France.
² Neuroendocrine Tumour Unit, Royal Free Hospital, London, United Kingdom.
³ Department of Pathology, University of Lyon, Lyon, France.
⁴ Department of Thoracic Surgery, University of Torino, Torino, Italy.
⁵ Department of Thoracic Surgery, Royal Brompton Hospital, London, United Kingdom.
⁶ Department of Pathophysiology, Division of Endocrinology, National University of Athens, Athens, Greece.
⁷ Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
⁸ Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
⁹ Slaska Akademia Medyczna Klinika Endokrynologii, Zabrze, Poland.
¹⁰ FSBI "N.N Blokhin Russian Cancer Research Centre," Russian Academy of Medical Sciences, Moscow, Russian Federation.
¹¹ Department of Hepatology and Gastroenterology, Campus Charité Mitte and Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, Berlin, Germany.
¹² Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands.
¹³ Department of Radiology, Faculty of Medical Sciences, University of Warmia and Mazury, Olsztyn, Poland.
¹⁴ Department of Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden.
¹⁵ Department of Medical Oncology, The Christie NHS Foundation Trust, University of Manchester/Institute of Cancer Sciences, Manchester, United Kingdom.
¹⁶ Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
¹⁷ Neuroendocrine Tumour Unit, Royal Free Hospital, London, United Kingdomm.caplin@ucl.ac.uk.
¹⁸ UKGM GmbH, Marburg, Germany.
¹⁹ University Hospital, Marburg, Germany.
²⁰ Institut Gustave, Roussy, France.
²¹ Memorial Sloan Kettering Cancer Center, USA.
²² Cliniques universitaires, Saint-Luc, Belgium.
²³ Vall d'Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO), Spain.
²⁴ Department of Medicine, Royal Free Hospital, UK.
²⁵ The First Affiliated Hospital, Sun Yat-Sen University, China.
²⁶ Oncoclin Medicos Associados S/S Ltda. c/o Frederico Costa - Regina Lima, Brazil.
²⁷ Hôpital Bichat, Service de Pathologie, France.
²⁸ Department of Radiology, Faculty of Medical Sciences, Univeristy of Warmia and Mazury, Poland.
²⁹ Erasmus MC, Department of Internal Medicine, Section of Endocrinology, The Netherlands.
³⁰ Department of Surgery, Università Vita e Salute, Italy.
³¹ Department of Endocrine Oncology, Uppsala University Hospital, Sweden.
³² European Institute of Oncology, Italy.
³³ University of Genova, Italy.
³⁴ Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, UK.
³⁵ Hospital Universitario Doce de Octubre, Spain.
³⁶ Royal Free Hospital, London, UK.
³⁷ Zentralklinik Bad Berka GmbH, CA Gastroenterologie, Germany.
³⁸ National Institutes of Health, USA.
³⁹ Endocrine Unit, Department of Pathophysiology, National University of Athens, Greece.
⁴⁰ Consultation Center for Pancreatic and Endocrine Tumors/Department of Pathology/TU-Munich, Germany.
⁴¹ Rigshospitalet, Department of Surgery (C2122), Denmark.
⁴² Department of Endocrinology and Neuroendocrine Tumors, Medical University of Silesia, Poland.
⁴³ Universitätsklinik für Innere Medizin, Austria.
⁴⁴ Erasmus MC, The Netherlands.
⁴⁵ Dana-Farber Cancer Institute, USA.
⁴⁶ Amsterdam Working Hospital, The Netherlands.
⁴⁷ Instituto Fleming, Argentina.
⁴⁸ St. James's and St Vincnt's Univerrsity Hospitals and Trinity College Dublin, Ireland.
⁴⁹ Charité Campus Mitte, Berlin, Germany.
⁵⁰ Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, "Vita-Salute" University, Milan, Italy.
⁵¹ Universitätsklinikum Erlangen, Germany.
⁵² Department of Oncology, Antwerp University Hospital, Belgium.
⁵³ Hampshire Hospitals NHS Trust, UK.
⁵⁴ Beatson Oncology Centre/Gartnavel General Hospital, UK.
⁵⁵ Policlinico Universitario A. Gemelli, Rome, Italy.
⁵⁶ Uniklinikum Giessen und Marburg, Germany.
⁵⁷ Department of Gastroenterology-Pancreatology, Beaujon Hospital, France.
⁵⁸ Haukeland University Hospital, Department of Oncology, Norway.
⁵⁹ Department of Radiology, Institute of Surgical Sciences, Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden.
⁶⁰ Gustave Roussy, Biopathology, France.
⁶¹ Netherlands Cancer Centre, The Netherlands.
⁶² Uppsala University, Sweden.
⁶³ University of Manchester/The Christie NHS Foundation Trust, UK.
⁶⁴ Hôpital Beaujon - Radiologie, France.
⁶⁵ Endocrine Oncology, University Hospital, Uppsala, Sweden.
⁶⁶ Gastroenterology, Charité Medical School and Hospital (Virchow), Germany.

PMID: 30248673
DOI: 10.1159/000493980

Abstract

Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- and intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.

Keywords: Bronchial carcinoid tumours; NET; Neuroendocrine neoplasms; Pulmonary carcinoids.

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Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms

Collaborators

Affiliations

Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms

Authors

Collaborators

Affiliations

Abstract

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LinkOut - more resources

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Medical