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. 2018 Sep 21;7(10):297.
doi: 10.3390/jcm7100297.

Effects of the Hormone Replacement Therapy and of Soy Isoflavones on Bone Resorption in Postmenopause

Delia Mirela Tit  1 , Simona Bungau  2 , Ciprian Iovan  3 , Delia Carmen Nistor Cseppento  4 , Laura Endres  5 , Cristian Sava  6 , Anca Maria Sabau  7 , Gheorghe Furau  8   9 , Cristian Furau  10   11
Affiliations

Effects of the Hormone Replacement Therapy and of Soy Isoflavones on Bone Resorption in Postmenopause

Delia Mirela Tit et al. J Clin Med. .

Abstract

Postmenopausal osteoporosis is the most common form of osteoporosis and one of the major public health problems in developed countries. The prevalence of this condition, associated with the physiological stage of menopause, is continuously increasing. This study evaluated the effectiveness of soy isoflavones as compared to hormone replacement therapy (HRT) in low doses, on the prevention of postmenopausal osteoporosis, by determining bone mineral density (BMD) and urinary deoxypyridinoline (D-pyr) in physiological postmenopausal women. The study was conducted over a period of 12 months, on three parallel groups, which included a total of 325 postmenopausal women (HRT group: n = 95; phytoestrogens group: n = 124; control group: n = 106). At the one-year evaluation, we observed T-score normalization in a small number of cases (5.26%, 2.42% and 0.00%, respectively). The average values of D-Pyr decreased by 11.38% in the group treated with phytoestrogens (p < 0.05) and by 15.32% in the group that followed HRT (p < 0.05); it increased by 4.38% in the control group (p > 0.05). Both therapies have beneficial effects on bone metabolism, leading to a significant decrease in the evolution of bone resorption and there are no major differences between the efficacy of HRT and phytoestrogens in terms of the effects on BMD and bone resorption.

Keywords: BMD; HRT; bone resorption; deoxypyridinoline; phytoestrogens.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The distribution of cases according to D-Pyr values > 6 nM/mM creatine.
Figure 2
Figure 2
The evolution of averages values of D-Pyr.
See this image and copyright information in PMC

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