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Review
. 2018 Sep 22;7(10):148.
doi: 10.3390/cells7100148.

Multifaceted Interweaving Between Extracellular Matrix, Insulin Resistance, and Skeletal Muscle

Khurshid Ahmad  1 , Eun Ju Lee  2 , Jun Sung Moon  3 , So-Young Park  4 , Inho Choi  5
Affiliations
Review

Multifaceted Interweaving Between Extracellular Matrix, Insulin Resistance, and Skeletal Muscle

Khurshid Ahmad et al. Cells. .

Abstract

The skeletal muscle provides movement and support to the skeleton, controls body temperature, and regulates the glucose level within the body. This is the core tissue of insulin-mediated glucose uptake via glucose transporter type 4 (GLUT4). The extracellular matrix (ECM) provides integrity and biochemical signals and plays an important role in myogenesis. In addition, it undergoes remodeling upon injury and/or repair, which is also related to insulin resistance (IR), a major cause of type 2 diabetes (T2DM). Altered signaling of integrin and ECM remodeling in diet-induced obesity is associated with IR. This review highlights the interweaving relationship between the ECM, IR, and skeletal muscle. In addition, the importance of the ECM in muscle integrity as well as cellular functions is explored. IR and skeletal muscle ECM remodeling has been discussed in clinical and nonclinical aspects. Furthermore, this review considers the role of ECM glycation and its effects on skeletal muscle homeostasis, concentrating on advanced glycation end products (AGEs) as an important risk factor for the development of IR. Understanding this complex interplay between the ECM, muscle, and IR may improve knowledge and help develop new ideas for novel therapeutics for several IR-associated myopathies and diabetes.

Keywords: advanced glycation end products; extracellular matrix; insulin resistance; skeletal muscle.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Muscle stem cells and the extracellular matrix (ECM) microenvironment.
Figure 2
Figure 2
Modifications of ECM components by advanced glycation end products (AGEs) and their effects.
See this image and copyright information in PMC

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References

    1. Kim K.M., Jang H.C., Lim S. Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia. Korean J. Intern. Med. 2016;31:643. doi: 10.3904/kjim.2016.015. - DOI - PMC - PubMed
    1. Yin H., Price F., Rudnicki M.A. Satellite cells and the muscle stem cell niche. Physiol. Rev. 2013;93:23–67. doi: 10.1152/physrev.00043.2011. - DOI - PMC - PubMed
    1. Shadrin I., Khodabukus A., Bursac N. Striated muscle function, regeneration, and repair. Cell. Mol. Life Sci. 2016;73:4175–4202. doi: 10.1007/s00018-016-2285-z. - DOI - PMC - PubMed
    1. Richter E.A., Hargreaves M. Exercise, GLUT4, and skeletal muscle glucose uptake. Physiol. Rev. 2013;93:993–1017. doi: 10.1152/physrev.00038.2012. - DOI - PubMed
    1. DeFronzo R., Jacot E., Jequier E., Maeder E., Wahren J., Felber J. The effect of insulin on the disposal of intravenous glucose: Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes. 1981;30:1000–1007. doi: 10.2337/diab.30.12.1000. - DOI - PubMed

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