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Review
. 2018 Sep 18:11:252.
doi: 10.1186/s13068-018-1252-3. eCollection 2018.

Exploitation of novel wild type solventogenic strains for butanol production

Fengxue Xin  1   2 , Wei Yan  1 , Jie Zhou  1   2 , Hao Wu  1   2 , Weiliang Dong  1   2 , Jiangfeng Ma  1   2 , Wenming Zhang  1   2 , Min Jiang  1   2
Affiliations
Review

Exploitation of novel wild type solventogenic strains for butanol production

Fengxue Xin et al. Biotechnol Biofuels. .

Abstract

Butanol has been regarded as an important bulk chemical and advanced biofuel; however, large scaling butanol production by solventogenic Clostridium sp. is still not economically feasible due to the high cost of substrates, low butanol titer and yield caused by the toxicity of butanol and formation of by-products. Renewed interests in biobutanol as biofuel and rapid development in genetic tools have spurred technological advances to strain modifications. Comprehensive reviews regarding these aspects have been reported elsewhere in detail. Meanwhile, more wild type butanol producers with unique properties were also isolated and characterized. However, few reviews addressed these discoveries of novel wild type solventogenic Clostridium sp. strains. Accordingly, this review aims to comprehensively summarize the most recent advances on wild type butanol producers in terms of fermentation patterns, substrate utilization et al. Future perspectives using these native ones as chassis for genetic modification were also discussed.

Keywords: Fermentation pattern; Novel genus; Solventogenic Clostridium sp.; Substrate utilization.

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Figures

Fig. 1
Fig. 1
The metabolic pathway for isopropanol–butanol–ethanol (IBE) production. The box shows the synthetic pathway for isopropanol production from acetone. ACoAAT acetyl-CoA acetyltransferase, ACoAT acetoacetyl-CoA transferase, ADC acetoacetate decarboxylase, SADH secondary alcohol dehydrogenase, ADH alcohol dehydrogenase, BDH butanol dehydrogenase
Fig. 2
Fig. 2
The metabolic pathway for acetone–butanol–ethanol (ABE) production from glucose, xylose and glycerol
See this image and copyright information in PMC

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