Metal-Mediated Functionalization of Natural Peptides and Proteins: Panning for Bioconjugation Gold
- PMID: 30251344
- DOI: 10.1002/anie.201807536
Metal-Mediated Functionalization of Natural Peptides and Proteins: Panning for Bioconjugation Gold
Abstract
Selective modification of natural proteins is a daunting methodological challenge and a stringent test of selectivity and reaction scope. There is a continued need for new reactivity and new selectivity concepts. Transition metals exhibit a wealth of unique reactivity that is orthogonal to biological reactions and processes. As such, metal-based methods play an increasingly important role in bioconjugation. This Review examines metal-based methods as well as their reactivity and selectivity for the functionalization of natural proteins and peptides.
Keywords: bioinorganic chemistry; metalation; peptides; protein modification; transition metals.
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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