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Review
. 2019 May 6;58(19):6176-6199.
doi: 10.1002/anie.201807536. Epub 2019 Mar 4.

Metal-Mediated Functionalization of Natural Peptides and Proteins: Panning for Bioconjugation Gold

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Review

Metal-Mediated Functionalization of Natural Peptides and Proteins: Panning for Bioconjugation Gold

Jun Ohata et al. Angew Chem Int Ed Engl. .

Abstract

Selective modification of natural proteins is a daunting methodological challenge and a stringent test of selectivity and reaction scope. There is a continued need for new reactivity and new selectivity concepts. Transition metals exhibit a wealth of unique reactivity that is orthogonal to biological reactions and processes. As such, metal-based methods play an increasingly important role in bioconjugation. This Review examines metal-based methods as well as their reactivity and selectivity for the functionalization of natural proteins and peptides.

Keywords: bioinorganic chemistry; metalation; peptides; protein modification; transition metals.

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