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Review
. 2019 May;28(5):529-537.
doi: 10.1177/0963689718794864. Epub 2018 Sep 25.

Application of Cord Blood and Cord Blood-Derived Induced Pluripotent Stem Cells for Cartilage Regeneration

Yeri Alice Rim  1 , Yoojun Nam  1 , Ji Hyeon Ju  1   2
Affiliations
Review

Application of Cord Blood and Cord Blood-Derived Induced Pluripotent Stem Cells for Cartilage Regeneration

Yeri Alice Rim et al. Cell Transplant. 2019 May.

Abstract

Regeneration of articular cartilage is of great interest in cartilage tissue engineering since articular cartilage has a low regenerative capacity. Due to the difficulty in obtaining healthy cartilage for transplantation, there is a need to develop an alternative and effective regeneration therapy to treat degenerative or damaged joint diseases. Stem cells including various adult stem cells and pluripotent stem cells are now actively used in tissue engineering. Here, we provide an overview of the current status of cord blood cells and induced pluripotent stem cells derived from these cells in cartilage regeneration. The abilities of these cells to undergo chondrogenic differentiation are also described. Finally, the technical challenges of articular cartilage regeneration and future directions are discussed.

Keywords: cartilage; chondrogenesis; cord blood; differentiation; induced pluripotent stem cell; tissue regeneration.

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Conflict of interest statement

Declaration of Conflicting Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Fig 1.
Fig 1.
Comparison of bone marrow-derived MSCs and cord blood-derived MSCs. The characteristics of each cell during harvest, culture are shown. HLA: human leukocyte antigen; MSC: mesenchymal stem cell.
Fig. 2.
Fig. 2.
Cartilage treatment using hUCB-derived cells. HLA-typed hUCB cells are stored in a private or public cord blood bank. MSCs isolated from hUCBs are commonly used for cartilage treatment. As a new cell source for cartilage regeneration, hiPSCs generated from hUCBs are a potentially new alternative to hUCB-derived MSC cells. Chondrogenic cells or tissues derived from hUCB-hiPSCs hold great potential for chondrogenesis and cartilage regeneration. The schema provides an overview of recent work on chondrogenesis and cartilage regeneration using hUCBs and hUCB-hiPSCs. hiPSC: human induced pluripotent stem cell; HLA: human leukocyte antigen; hUCB: human umbilical cord blood; MSC: mesenchymal stem cell.
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