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. 2019 Mar;25(5-6):303-313.
doi: 10.1089/ten.TEA.2018.0170. Epub 2018 Nov 9.

Injectable Chitosan Hydrogels with Enhanced Mechanical Properties for Nucleus Pulposus Regeneration

Yasaman Alinejad  1   2   3 , Atma Adoungotchodo  1   2   3 , Michael P Grant  3 , Laura M Epure  3 , John Antoniou  3   4 , Fackson Mwale  3   4 , Sophie Lerouge  1   2
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Injectable Chitosan Hydrogels with Enhanced Mechanical Properties for Nucleus Pulposus Regeneration

Yasaman Alinejad et al. Tissue Eng Part A. 2019 Mar.

Abstract

A thermosensitive chitosan-based hydrogel was developed, which mimics the mechanical properties of the human nucleus pulposus (NP) tissue and provides a suitable environment for seeded NP cells to live and produce glycosaminoglycans. This scaffold is injectable through 25G needle and rapidly gels in vivo at body temperature. It has the potential to restore mechanical properties and stimulate biological repair of the degenerated intervertebral disc (IVD). It could therefore be used for the minimally invasive treatment of degenerated IVD, which affects more than one person out of five in the world.

Keywords: chitosan; hydrogel; intervertebral disc; mechanical properties; nucleus pulposus.

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