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Book

Cryptococcal Meningitis

Marco A. Pescador Ruschel  1 , Bicky Thapa  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Free Books & Documents
Book

Cryptococcal Meningitis

Marco A. Pescador Ruschel et al.
Free Books & Documents

Excerpt

Cryptococcosis is an important opportunistic infection that causes more than 100,000 HIV-related deaths each year. It was named the Busse-Buschke disease because of its first description by Otto Busse and Abraham Buschke in 1894.

Even though the infection is usually HIV-related, in many centers (especially in developed countries), most of the non-HIV-related cases include patients under immunosuppressive treatments or with organic failure syndromes, transplants, innate immunological problems, common variable immunodeficiency syndrome, and hematological disorders.

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Conflict of interest statement

Disclosure: Marco Pescador Ruschel declares no relevant financial relationships with ineligible companies.

Disclosure: Bicky Thapa declares no relevant financial relationships with ineligible companies.

References

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    1. Pappas PG. Cryptococcal infections in non-HIV-infected patients. Trans Am Clin Climatol Assoc. 2013;124:61-79. - PMC - PubMed
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    1. Williamson PR, Jarvis JN, Panackal AA, Fisher MC, Molloy SF, Loyse A, Harrison TS. Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy. Nat Rev Neurol. 2017 Jan;13(1):13-24. - PubMed
    1. Rittershaus PC, Kechichian TB, Allegood JC, Merrill AH, Hennig M, Luberto C, Del Poeta M. Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans. J Clin Invest. 2006 Jun;116(6):1651-9. - PMC - PubMed

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