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Book

Antacids

Blake H. Salisbury  1 , Jamie M. Terrell  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Affiliations
Book

Antacids

Blake H. Salisbury et al.

Excerpt

Antacids are a group of drugs that have been on the market for many years. They were initially first-line defense against peptic ulcer disease; however, the discovery of proton pump inhibitors revolutionized the treatment of peptic ulcer disease. Currently, antacid use is restricted to relieve mild intermittent gastroesophageal reflux disease (GERD) with associated heartburn. This activity reviews the indications, contraindications, pharmaceutical action, adverse events, and other key elements of antacid therapy in the clinical setting as relates to the essential points needed by members of an interprofessional team managing the care of patients with heartburn and mild GERD.

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Conflict of interest statement

Disclosure: Blake Salisbury declares no relevant financial relationships with ineligible companies.

Disclosure: Jamie Terrell declares no relevant financial relationships with ineligible companies.

References

    1. Sontag SJ. The medical management of reflux esophagitis. Role of antacids and acid inhibition. Gastroenterol Clin North Am. 1990 Sep;19(3):683-712. - PubMed
    1. El-Serag HB, Sweet S, Winchester CC, Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014 Jun;63(6):871-80. - PMC - PubMed
    1. Moayyedi P, Axon AT. Review article: gastro-oesophageal reflux disease--the extent of the problem. Aliment Pharmacol Ther. 2005 Aug;22 Suppl 1:11-9. - PubMed
    1. Shaker R, Castell DO, Schoenfeld PS, Spechler SJ. Nighttime heartburn is an under-appreciated clinical problem that impacts sleep and daytime function: the results of a Gallup survey conducted on behalf of the American Gastroenterological Association. Am J Gastroenterol. 2003 Jul;98(7):1487-93. - PubMed
    1. Eisen G. The epidemiology of gastroesophageal reflux disease: what we know and what we need to know. Am J Gastroenterol. 2001 Aug;96(8 Suppl):S16-8. - PubMed

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