Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Ibuprofen Toxicity

Muhammed Ershad, Muhammad Atif Ameer  1 , Richard J. Chen  2 , David Vearrier  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Ibuprofen Toxicity

Muhammed Ershad et al.
Free Books & Documents

Excerpt

Ibuprofen, 2-(4-isobutylphenyl) propionic acid, belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs) and was discovered by Dr. Stewart Adams in 1961. The drug was first marketed in 1969 in the United Kingdom and in 1974 in the United States. Ibuprofen is commonly prescribed as an analgesic, antipyretic, and anti-inflammatory agent in conditions such as osteoarthritis, rheumatoid arthritis, juvenile idiopathic arthritis, and acute musculoskeletal pain. Off-label applications include its use in conditions such as cystic fibrosis to slow progression. Ibuprofen is also used to close patent ductus arteriosus in neonates. This resource serves to review ibuprofen's essential pharmacological characteristics, clinical presentations during an overdose, and management of ibuprofen toxicity.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Muhammed Ershad declares no relevant financial relationships with ineligible companies.

Disclosure: Muhammad Atif Ameer declares no relevant financial relationships with ineligible companies.

Disclosure: Richard Chen declares no relevant financial relationships with ineligible companies.

Disclosure: David Vearrier declares no relevant financial relationships with ineligible companies.

References

    1. Halford GM, Lordkipanidzé M, Watson SP. 50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams. Platelets. 2012;23(6):415-22. - PubMed
    1. Konstan MW, VanDevanter DR, Sawicki GS, Pasta DJ, Foreman AJ, Neiman EA, Morgan WJ. Association of High-Dose Ibuprofen Use, Lung Function Decline, and Long-Term Survival in Children with Cystic Fibrosis. Ann Am Thorac Soc. 2018 Apr;15(4):485-493. - PubMed
    1. Chen Q, Ilanga M, Simbassa SB, Chirra B, Shah KN, Cannon CL. Synergistic Antimicrobial Effects of Ibuprofen Combined with Standard-of-Care Antibiotics against Cystic Fibrosis Pathogens. Biomedicines. 2023 Oct 30;11(11) - PMC - PubMed
    1. Mitra S, Weisz D, Jain A, Jong G'. Management of the patent ductus arteriosus in preterm infants. Paediatr Child Health. 2022 Mar;27(1):63-64. - PMC - PubMed
    1. Yeung T, Shahroor M, Jain A, Weisz D, Jasani B. Efficacy and safety of high versus standard dose ibuprofen for patent ductus arteriosus treatment in preterm infants: A systematic review and meta-analysis. J Neonatal Perinatal Med. 2022;15(3):501-510. - PubMed

Publication types

LinkOut - more resources