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. 2018;14(4):159-162.
doi: 10.1080/15476278.2018.1517508. Epub 2018 Sep 25.

Xenotransplantation

Srijan Tandukar  1 , Sundaram Hariharan  1
Affiliations

Xenotransplantation

Srijan Tandukar et al. Organogenesis. 2018.

Abstract

The transplantation of living cells, tissues or organs from one species to another is termed xenotransplantation. The history of xenotransplantation is as old as allogeneic transplantation itself. Early attempts were made at a time when the immunologic basis of organ rejection were poorly understood. The advent of potent immunosuppressive medications along with the parallel advances in the field of genetic engineering has provided a fresh perspective on the role of xenotransplantation as a means to alleviate the disparity between the number of candidates on the waitlist and the available organs. As the science behind xenotransplantation advances, the transplantation community must take it upon themselves to educate the community at large regarding both the benefits and potential risks of this promising field.

Keywords: solid organ xenotransplantation; xenograft; xenotransplantation.

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References

    1. Salomon DR. A CRISPR way to block PERVs–engineering organs for transplantation. N Engl J Med. 2016. March 17;374(11):1089–1091. doi: 10.1056/NEJMcibr1515623. - DOI - PubMed
    1. Cooper DKC, Ekser B, Ramsoondar J, Phelps C, Ayares D.. The role of genetically engineered pigs in xenotransplantation research. J Pathol. 2016. January;238(2):288–299. doi: 10.1002/path.4635. - DOI - PMC - PubMed
    1. Reemtsma K, Mccracken BH, Schlegel JU, Pearl M. Heterotransplantation of the kidney: two clinical experiences. Science. 1964. February 14;143(3607):700–702. doi: 10.1126/science.143.3607.700. - DOI - PubMed
    1. Cooper DKC, Ekser B, Tector AJ. A brief history of clinical xenotransplantation. IntJ Surg. 2015. November;23(Pt B):205–210. doi: 10.1016/j.ijsu.2015.06.060. - DOI - PMC - PubMed
    1. Ekser B, Li P, Cooper DKC. Xenotransplantation: past, present, and future. Curr Opin Organ Transplant. 2017. December;22(6):513–521. - PMC - PubMed

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