[Immunohistological study on malignant and premalignant lesions of the uterine cervix associated with herpes simplex virus]

Abstract

Herpes Simplex Virus 2 (HSV-2) has become the object of public attention as an etiological cause of cervical cancer. Uneven distribution of HSV antigen in tissue was examined dy dyeing tissue materials of cervical intraepithelial neoplasia by the method called peroxidase-antiperoxidase using HSV-2 antibody. The positive rate in the control group was 10.3%, while it was 10.7% in the mild dysplasia group, 17.5% in the moderate dysplasia group, 25.5% in the severe dysplasia group, 31.3% in the carcinoma in situ (CIS) group and 41.4% in the cervical cancer group. The positive rate in the cervical cancer group showed a significant difference from the control, mild displasia, moderate dysplasia and severe dysplasia groups (p less than 0.01). The rate in the CIS group demonstrated a significant difference from the control and mild dysplasia groups (p less than 0.05, p less than 0.01). The rate in the severe dysplasia group showed a significant difference from the control and mild dysplasia groups (p less than 0.05, p less than 0.01). The positive rate in the cervical cancer group in patients 40 approximately 49 years of age was significantly higher than that in the control and mild dysplasia groups (p less than 0.01). It also showed a significant difference from the moderate dysplasia and severe dysplasia groups (p less than 0.05). The rate in the cervical cancer group in patients aged 50 approximately 59 years showed a significant difference from the control, moderate dysplasia and mild dysplasia groups (p less than 0.05, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)