Super-Competitors Game the Fitness Sensing System
- PMID: 30253165
- DOI: 10.1016/j.devcel.2018.09.006
Super-Competitors Game the Fitness Sensing System
Abstract
Competitive interactions between neighboring cells require fitness comparison and local killing, but the signals regulating these processes are unknown. In this issue, Alpar et al. (2018) demonstrate that fitter cells secrete serine proteases to create a local burst of active Spätzle, triggering Toll signaling and apoptosis in less fit neighbors.
Copyright © 2018 Elsevier Inc. All rights reserved.
Comment on
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Spatially Restricted Regulation of Spätzle/Toll Signaling during Cell Competition.Dev Cell. 2018 Sep 24;46(6):706-719.e5. doi: 10.1016/j.devcel.2018.08.001. Epub 2018 Aug 23. Dev Cell. 2018. PMID: 30146479 Free PMC article.
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