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Comment
. 2018 Sep 24;46(6):678-679.
doi: 10.1016/j.devcel.2018.09.007.

Rapping about Mechanotransduction

Consuelo Ibar  1 , Kenneth D Irvine  2
Affiliations
Free article
Comment

Rapping about Mechanotransduction

Consuelo Ibar et al. Dev Cell. .
Free article

Abstract

Mechanical cues can regulate cell proliferation and differentiation through the Hippo-YAP signaling network. Reporting in Nature, Meng et al. (2018) show that the Ras-related GTPase RAP2 connects extracellular matrix stiffness to Hippo pathway regulation, adding to our understanding of how mechanical cues are converted into changes in YAP activity.

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  • RAP2 mediates mechanoresponses of the Hippo pathway.
    Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. Meng Z, et al. Nature. 2018 Aug;560(7720):655-660. doi: 10.1038/s41586-018-0444-0. Epub 2018 Aug 22. Nature. 2018. PMID: 30135582 Free PMC article.

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