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. 2018 Oct 5:158:874-883.
doi: 10.1016/j.ejmech.2018.09.011. Epub 2018 Sep 15.

Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives

Aitor Maestro, Endika Martín-Encinas, Concepción Alonso, Edorta Martinez de Marigorta, Gloria Rubiales, Javier Vicario, Francisco Palacios

Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives

Aitor Maestro et al. Eur J Med Chem. .

Abstract

An efficient synthetic methodology for the preparation of phosphorus substituted bis-(3-indolyl)methane through a double nucleophilic addition of indole derivatives to an in situ generated α-iminophosphonate is reported. In addition, bis-(3-indolyl)methane substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell lines A549 (carcinomic human alveolar basal epithelial cell) and SKOV03 (human ovarian carcinoma).

Keywords: Antiproliferative effect; Bis-(3-indolyl)methanes (BIMs); Indole; Phosphonate.

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